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    arsB arsenite/antimonite:H(+) antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948011, updated on 17-Dec-2024

    Summary

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    Official Symbol
    arsB
    Official Full Name
    arsenite/antimonite:H(+) antiporter
    Primary source
    ECOCYC:EG12236
    Locus tag
    b3502
    See related
    ASAP:ABE-0011437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    arsF; ECK3487
    Summary
    ArsB can function alone using PMF to drive transport, as is the case with the chromosomal ArsB, which lacks the ArsA ATPase; ArsB proteins can use ATP to drive efflux if ArsA is present. [More information is available at EcoGene: EG12236]. Based on sequence similarity with the R773-plasmid encoded arsenite resistance operon, ArsB is a transporter and ArsC is an arsenate reductase . [More information is available at EcoCyc: EG12236].
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    Genomic context

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    Sequence:
    NC_000913.3 (3648935..3650224)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional repressor ArsR Neighboring gene arsenate reductase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ArsD: an As(III) metallochaperone for the ArsAB As(III)-translocating ATPase. Lin YF, et al. J Bioenerg Biomembr, 2007 Dec. PMID 17955352
    2. Use of a luminescent bacterial biosensor for biomonitoring and characterization of arsenic toxicity of chromated copper arsenate (CCA). Cai J, et al. Biodegradation, 1997. PMID 9342883
    3. An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria. Diorio C, et al. J Bacteriol, 1995 Apr. PMID 7721697, Free PMC Article
    4. The ars operon of Escherichia coli confers arsenical and antimonial resistance. Carlin A, et al. J Bacteriol, 1995 Feb. PMID 7860609, Free PMC Article
    5. As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli. Meng YL, et al. J Biol Chem, 2004 Apr 30. PMID 14970228

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. review of ArsAB and ArsD function
      Title: ArsD: an As(III) metallochaperone for the ArsAB As(III)-translocating ATPase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antimonite secondary active transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antimonite secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arsenite secondary active transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arsenite secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arsenite transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antimonite transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arsenite transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within arsenite transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arsenite transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arsenite/antimonite:H(+) antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3648935..3650224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417959.4 arsenite/antimonite:H(+) antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417959.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JAS4
      Conserved Domains (1) summary
      PRK15445
      Location:2 → 428
      PRK15445; arsenical efflux pump membrane protein ArsB
    Nucleotide Protein
    Heading Accession and Version

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