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    dtpA dipeptide/tripeptide:H(+) symporter DtpA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947436, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dtpA
    Official Full Name
    dipeptide/tripeptide:H(+) symporter DtpA
    Primary source
    ECOCYC:G6877
    Locus tag
    b1634
    See related
    ASAP:ABE-0005469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1630; tppB; ydgR
    Summary
    Overexpression increases di- and tri-peptide transport and confers hypersensitivity to alafosfalin (Weitz, 2006). [More information is available at EcoGene: EG13939]. The YdgR protein is a member of the POT family of peptide transporters . [More information is available at EcoCyc: G6877].
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    Genomic context

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    Sequence:
    NC_000913.3 (1712769..1714271)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene SoxR [2Fe-2S] reducing system protein RsxG Neighboring gene SoxR [2Fe-2S] reducing system protein RsxE Neighboring gene endonuclease III Neighboring gene glutathione S-transferase GstA Neighboring gene pyridoxal kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Prabhala BK, et al. Res Microbiol, 2017 Jun. PMID 28214542
    2. Simultaneous exploitation of different peptide permeases by combinations of synthetic peptide smugglins can lead to enhanced antibacterial activity. Smith MW, et al. FEMS Microbiol Lett, 1990 Aug. PMID 2227366
    3. Peptide transport in bacteria. Higgins CF, et al. Methods Enzymol, 1986. PMID 3520226
    4. The number and nature of the peptide-transport systems of Escherichia coli: characterization of specific transport mutants. Alves RA, et al. Biochem Soc Trans, 1980 Dec. PMID 7007121
    5. Functional and structural characterization of a prokaryotic peptide transporter with features similar to mammalian PEPT1. Weitz D, et al. J Biol Chem, 2007 Feb 2. PMID 17158458

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
      Title: The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells.
    2. findings show YdgR can transport 5 drugs. cCells not overexpressing YdgR were also able to transport these drugs in a proton-dependent oligopeptide transporter-like manner; orthologues of YdgR are found in several species in the gut microbiome; findings could have implications for further understanding the interaction of gut microbes and orally administered drugs
      Title: Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR.
    3. DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli
      Title: DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide:proton symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tripeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tripeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tripeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dipeptide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dipeptide transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dipeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligopeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tripeptide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tripeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptide/tripeptide:H(+) symporter DtpA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1712769..1714271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416151.1 dipeptide/tripeptide:H(+) symporter DtpA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416151.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3P5DNZ8
      Conserved Domains (1) summary
      PRK09584
      Location:1 → 487
      tppB; dipeptide/tripeptide permease DtpA
    Nucleotide Protein
    Heading Accession and Version

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