malT DNA-binding transcriptional activator MalT [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: malT
Official Full Name: DNA-binding transcriptional activator MalT
Primary source: ECOCYC:EG10562
Locus tag: b3418
See related: ASAP:ABE-0011162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3405; malA
Summary: Activated by maltotriose and ATP to form active oligomers. [More information is available at EcoGene: EG10562]. The malT gene is located upstream of and in the opposite direction of the operon malPQ . [More information is available at EcoCyc: EG10562].
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Genomic context

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Sequence:: NC_000913.3 (3553085..3555790)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
Title: Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
pinpointed the NOD-arm interface of the MalT STAND transcription factor, and generated a MalT variant in which this interface can be covalently locked on demand, thereby trapping the NOD in the closed state
Title: How 'arm-twisting' by the inducer triggers activation of the MalT transcription factor, a typical signal transduction ATPase with numerous domains (STAND).
The molecular entity that interacts with MalT is not free MalK, but the maltose transporter, MalFGK(2) , which sequesters MalT to the membrane.
Title: The ABC transporter MalFGK(2) sequesters the MalT transcription factor at the membrane in the absence of cognate substrate.
The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT.
Title: The inducer maltotriose binds in the central cavity of the tetratricopeptide-like sensor domain of MalT, a bacterial STAND transcription factor.
Substitutions of R171 impaired both ATP hydrolysis and multimerization, which is consistent with an arginine finger function and provides further evidence that ATP hydrolysis is primarily catalyzed by MalT multimers.
Title: Conserved motifs involved in ATP hydrolysis by MalT, a signal transduction ATPase with numerous domains from Escherichia coli.
Data report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
Title: A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
Overexpression of glk leads to a reduction in mal gene expression and interpret of this repression is a direct interaction of Glk with MalT concomitant with MalT inhibition.
Title: Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.
ATPase activity of malT is not essential for downstream signaling but plays a key role in the integration of regulatory signals.
Title: How integration of positive and negative regulatory signals by a STAND signaling protein depends on ATP hydrolysis.
Data suggest that the MalT/MalK interaction might involve two distinct contact sites on each partner.
Title: Two domains of MalT, the activator of the Escherichia coli maltose regulon, bear determinants essential for anti-activation by MalK.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables trisaccharide binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-binding transcriptional activator MalT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3553085..3555790

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417877.1 DNA-binding transcriptional activator MalT [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417877.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A8S7JLT0

Conserved Domains (1) summary

PRK04841
Location:1 → 900

PRK04841; HTH-type transcriptional regulator MalT