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    cysI sulfite reductase, hemoprotein subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947231, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cysI
    Official Full Name
    sulfite reductase, hemoprotein subunit
    Primary source
    ECOCYC:EG10190
    Locus tag
    b2763
    See related
    ASAP:ABE-0009061
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2758
    Summary
    Contains one siroheme and one 4-Fe-4S iron-sulfur center per chain. [More information is available at EcoCyc: EG10190].
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    Genomic context

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    Sequence:
    NC_000913.3 (2888387..2890099, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphoadenosine phosphosulfate reductase Neighboring gene sulfite reductase, flavoprotein subunit Neighboring gene 6-carboxy-5,6,7,8-tetrahydropterin synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. Crane BR, et al. Biochemistry, 1997 Oct 7. PMID 9315848
    2. Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex. Christner JA, et al. J Biol Chem, 1983 Sep 25. PMID 6309833
    3. Proton NMR of Escherichia coli sulfite reductase: studies of the heme protein subunit with added ligands. Kaufman J, et al. Biochemistry, 1993 Aug 31. PMID 8395881
    4. Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit. Kaufman J, et al. Biochemistry, 1993 Mar 23. PMID 8457551
    5. Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. Crane BR, et al. Biochemistry, 1997 Oct 7. PMID 9315849

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase.
      Title: Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase.
    2. A model is proposed for the inhibition of growth in which the reduction of furfural by YqhD enzyme depletes NADPH sufficiently to limit the assimilation of sulfur into amino acids (cysteine and methionine) by CysIJ (sulfite reductase).
      Title: Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfite reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of sulfite reductase complex (NADPH) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sulfite reductase complex (NADPH) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sulfite reductase complex (NADPH) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sulfite reductase complex (NADPH) IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfite reductase, hemoprotein subunit
    NP_417243.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2888387..2890099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417243.1 sulfite reductase, hemoprotein subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417243.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A485JA78
      Conserved Domains (1) summary
      PRK13504
      Location:5 → 569
      PRK13504; NADPH-dependent assimilatory sulfite reductase hemoprotein subunit
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials