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    hycC formate hydrogenlyase subunit HycC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945327, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hycC
    Official Full Name
    formate hydrogenlyase subunit HycC
    Primary source
    ECOCYC:EG10476
    Locus tag
    b2723
    See related
    ASAP:ABE-0008948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2718; hevC
    Summary
    FhlA regulon. [More information is available at EcoGene: EG10476]. HycC encodes an extremely hydrophobic protein with 12 to 16 predicted transmembrane domains. [More information is available at EcoCyc: EG10476].
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    Genomic context

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    Sequence:
    NC_000913.3 (2847415..2849241, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate hydrogenlyase subunit HycE Neighboring gene formate hydrogenlyase subunit HycD Neighboring gene formate hydrogenlyase subunit HycB Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase 3 nickel incorporation protein HypA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate. Mnatsakanyan N, et al. Cell Biochem Biophys, 2004. PMID 15509886
    2. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
    3. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
    4. Regulation of gene expression in fermentative and respiratory systems in Escherichia coli and related bacteria. Lin EC, et al. Annu Rev Genet, 1991. PMID 1812811
    5. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hyd-3 has a major role in H2 production at acidic pH independently on the F(0)F(1)-ATPase
      Title: Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formate oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of formate dehydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formate hydrogenlyase subunit HycC
    NP_417203.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2847415..2849241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417203.1 formate hydrogenlyase subunit HycC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417203.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376D4B0
      Conserved Domains (1) summary
      PRK08042
      Location:16 → 608
      PRK08042; formate hydrogenlyase subunit 3; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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