U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rof modulator of Rho-dependent transcription termination [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944891, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rof
    Official Full Name
    modulator of Rho-dependent transcription termination
    Primary source
    ECOCYC:G6097
    Locus tag
    b0189
    See related
    ASAP:ABE-0000641
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0188; yaeO
    Summary
    This is the real "mesJ" minE suppressor, not yaeN. [More information is available at EcoGene: EG13221]. Rof interacts with the Rho terminator protein and inhibits binding of RNA to Rho, thus showing antiterminator activity . [More information is available at EcoCyc: G6097].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (213678..213932, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene VOC domain-containing protein YaeR Neighboring gene tRNA(Ile)-lysidine synthetase Neighboring gene PF06786 family protein YaeP Neighboring gene uncharacterized protein YaeQ Neighboring gene peptidyl-tRNA hydrolase, ribosome rescue factor Neighboring gene sensor lipoprotein NlpE

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Solution structure of YaeO, a Rho-specific inhibitor of transcription termination. Gutiérrez P, et al. J Biol Chem, 2007 Aug 10. PMID 17565995
    2. Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli. Morita T, et al. mBio, 2022 Dec 20. PMID 36226957, Free PMC Article
    3. The Sm-like RNA chaperone Hfq mediates transcription antitermination at Rho-dependent terminators. Rabhi M, et al. EMBO J, 2011 Jun 14. PMID 21673658, Free PMC Article
    4. Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation. Kawamura N, et al. Genes Cells, 2005 May. PMID 15836776
    5. A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification. Hoving S, et al. Anal Chem, 2000 Mar 1. PMID 10739205

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
      Title: Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
    2. N-terminus verified by Edman degradation on complete protein
      Title: A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification.
    3. the negative character of YaeO is essential for its function as a Rho-specific inhibitor of transcription termination in vivo, as shown by its solution structure
      Title: Solution structure of YaeO, a Rho-specific inhibitor of transcription termination.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of termination of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription antitermination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    modulator of Rho-dependent transcription termination

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      213678..213932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414731.2 modulator of Rho-dependent transcription termination [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414731.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3MMH6, A0A148HV81, A0A1X0PPM4, A0A1X0PS29, A0A829L277, B1LGZ1, B7MP49, B7N856, B7UJ90, D3GRD4
      Conserved Domains (1) summary
      PRK11625
      Location:1 → 84
      PRK11625; Rho-binding antiterminator; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.