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    safA two-component system connector SafA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946061, updated on 3-Dec-2024

    Summary

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    Official Symbol
    safA
    Official Full Name
    two-component system connector SafA
    Primary source
    ECOCYC:G6790
    Locus tag
    b1500
    See related
    ASAP:ABE-0004994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4475; yneN
    Summary
    A yneN(b1500) mutant has 3-fold lower acid resistance and is regulated by EvgA as the first gene in the yneN(b1500)-ydeO operon (Masuda, 2002). yneN is activated by EvgA to stimulate genes downstream of PhoP in a PhoP-dependent manner by binding to PhoQ in the membrane, although the start site was not verified, the cloned gene effects are not IPTG-dependent and no native protein expression was demonstrated (Eguki, 2007). [More information is available at EcoGene: EG14466]. B1500 is involved in signal transduction between the EvgS/EvgA and PhoQ/PhoP two-component signal transduction systems. [More information is available at EcoCyc: G6790].
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    Genomic context

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    Sequence:
    NC_000913.3 (1583762..1583959, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sulfatase YdeN Neighboring gene DNA-binding transcriptional dual regulator YdeO Neighboring gene putative oxidoreductase YdeP Neighboring gene putative fimbrial adhesin protein YdeQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel aspects of the acid response network of E. coli K-12 are revealed by a study of transcriptional dynamics. Burton NA, et al. J Mol Biol, 2010 Sep 3. PMID 20603130
    2. The structure and insertion of integral proteins in membranes. Singer SJ. Annu Rev Cell Biol, 1990. PMID 2275815
    3. Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control. Yoshitani K, et al. Biosci Biotechnol Biochem, 2019 Apr. PMID 30632929
    4. Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli. Eguchi Y, et al. J Bacteriol, 2011 Mar. PMID 21193607, Free PMC Article
    5. Response acceleration in post-translationally regulated genetic circuits. Mitrophanov AY, et al. J Mol Biol, 2010 Mar 12. PMID 19932119, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to acidic pH EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    two-component system connector SafA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1583762..1583959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416017.1 two-component system connector SafA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416017.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N0IEH9
      Conserved Domains (1) summary
      pfam17073
      Location:1 → 64
      SafA; Two-component-system connector protein
    Nucleotide Protein
    Heading Accession and Version

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