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    glrK histidine kinase GlrK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947013, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glrK
    Official Full Name
    histidine kinase GlrK
    Primary source
    ECOCYC:G7345
    Locus tag
    b2556
    See related
    ASAP:ABE-0008409
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2553; qseE; yfhK; yfhZ
    Summary
    Characterized in an EPEC strain, QseC activates transcription of qseEGF in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). [More information is available at EcoGene: EG13461]. Purified YfhK can transphosphorylate its cognate response regulator YfhA in vitro . [More information is available at EcoCyc: G7345].
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    Genomic context

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    Sequence:
    NC_000913.3 (2689671..2691098, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nitrogen regulatory protein PII-1 Neighboring gene DNA-binding transcriptional activator GlrR Neighboring gene outer membrane lipoprotein QseG Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamide synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the sensor domain of QseE histidine kinase from Escherichia coli. Yeo KJ, et al. Protein Expr Purif, 2016 Oct. PMID 27371359
    2. Small RNA-binding protein RapZ mediates cell envelope precursor sensing and signaling in Escherichia coli. Khan MA, et al. EMBO J, 2020 Mar 16. PMID 32065419, Free PMC Article
    3. Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli. Göpel Y, et al. PLoS Genet, 2018 Jul. PMID 30040820, Free PMC Article
    4. Compilation of all genes encoding two-component phosphotransfer signal transducers in the genome of Escherichia coli. Mizuno T. DNA Res, 1997 Apr 28. PMID 9205844
    5. Dual control by perfectly overlapping sigma 54- and sigma 70- promoters adjusts small RNA GlmY expression to different environmental signals. Reichenbach B, et al. Mol Microbiol, 2009 Dec. PMID 19843219

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reveal a three-component signaling system in E. coli K-12, in which membrane-bound QseE is stimulated through interaction with periplasmic QseG to phosphorylate cytoplasmic QseF.
      Title: Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli.
    2. QseE and QseF are involved in the transcriptional control of genes necessary for pedestal formation
      Title: The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, carboxyl group as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular chemical homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in osmosensory signaling via phosphorelay pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to epinephrine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histidine kinase GlrK
    NP_417051.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2689671..2691098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417051.2 histidine kinase GlrK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417051.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CLI5
      Conserved Domains (1) summary
      COG0642
      Location:148 → 469
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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