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    purH bifunctional AICAR transformylase/IMP cyclohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948503, updated on 17-Dec-2024

    Summary

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    Official Symbol
    purH
    Official Full Name
    bifunctional AICAR transformylase/IMP cyclohydrolase
    Primary source
    ECOCYC:EG10795
    Locus tag
    b4006
    See related
    ASAP:ABE-0013097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3998
    Summary
    From the earliest studies an association between AICAR transformylase and IMP cyclohydrolase has been shown. [More information is available at EcoCyc: EG10795].
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    Genomic context

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    Sequence:
    NC_000913.3 (4205943..4207532, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase ZraS Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli. Qiu X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Dec 1. PMID 22139174, Free PMC Article
    2. Purine biosynthesis in Escherichia coli K12: structure and DNA sequence studies of the purHD locus. Flannigan KA, et al. Mol Microbiol, 1990 Mar. PMID 2192230
    3. Fine mapping of the rrnE, purHD, and hydGH operons on the Escherichia coli chromosome. Peterson JW, et al. J Bacteriol, 1991 Jun. PMID 2045358, Free PMC Article
    4. The effect of DnaA protein levels and the rate of initiation at oriC on transcription originating in the ftsQ and ftsA genes: in vivo experiments. Masters M, et al. Mol Gen Genet, 1989 Apr. PMID 2546042
    5. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystals of PurH diffracted to a maximum resolution of 3.05 A and belonged to the monoclinic space group P2(1), with unit-cell parameters a = 76.37, b = 132.15, c = 82.64 A, beta = 111.86 degrees
      Title: Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables IMP cyclohydrolase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables IMP cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional AICAR transformylase/IMP cyclohydrolase
    NP_418434.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4205943..4207532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418434.1 bifunctional AICAR transformylase/IMP cyclohydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418434.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FUH9
      Conserved Domains (1) summary
      PRK00881
      Location:4 → 529
      purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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