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    lpxK tetraacyldisaccharide 4'-kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945526, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lpxK
    Official Full Name
    tetraacyldisaccharide 4'-kinase
    Primary source
    ECOCYC:EG11409
    Locus tag
    b0915
    See related
    ASAP:ABE-0003115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0906; ycaH
    Summary
    Tetraacyldisaccharide 4'-kinase (LpxK) catalyzes the sixth step in lipid A biosynthesis. [More information is available at EcoCyc: EG11409].
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    Genomic context

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    Sequence:
    NC_000913.3 (968366..969352)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene integration host factor subunit beta Neighboring gene metallo-beta-lactamase superfamily inner membrane protein YcaI Neighboring gene ATP-binding lipopolysaccharide transport protein Neighboring gene interstrand DNA crosslink repair glycosylase Neighboring gene PF03966 family protein YcaR Neighboring gene 3-deoxy-manno-octulosonate cytidylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. Garrett TA, et al. J Biol Chem, 1997 Aug 29. PMID 9268317
    2. The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. Ray BL, et al. J Biol Chem, 1987 Jan 25. PMID 3027079
    3. Lipid A 4'-kinase from Escherichia coli: enzyme assay and preparation of 4'-32P-labeled probes of high specific radioactivity. Hampton RY, et al. Methods Enzymol, 1992. PMID 1323052
    4. The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Karow M, et al. Mol Microbiol, 1993 Jan. PMID 8094880
    5. Lipid A modification systems in gram-negative bacteria. Raetz CR, et al. Annu Rev Biochem, 2007. PMID 17362200, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetraacyldisaccharide 4'-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetraacyldisaccharide 4'-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tetraacyldisaccharide 4'-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetraacyldisaccharide 4'-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraacyldisaccharide 4'-kinase
    NP_415435.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      968366..969352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415435.1 tetraacyldisaccharide 4'-kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415435.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0MX50
      Conserved Domains (1) summary
      PRK00652
      Location:1 → 321
      lpxK; tetraacyldisaccharide 4'-kinase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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