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    18w 18 wheeler [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    18wprovided by FlyBase
    Official Full Name
    18 wheelerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287775
    Locus tag
    Dmel_CG8896
    See related
    AllianceGenome:FB:FBgn0287775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    18-w; 18-wheeler; 18W; CG8896; CT25100; Dmel\CG8896; EP-709; l(2)00053; tlr; toll; toll-2; Toll-2; Toll2
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including antibacterial humoral response; convergent extension; and oogenesis. Located in plasma membrane. Is expressed in several structures, including epithelium; follicle cell; gut section; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See 18w in Genome Data Viewer
    Location:
    56F8-56F8; 2-90 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20111511..20116932)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15999016..16004437)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44632 Neighboring gene long non-coding RNA:CR44633 Neighboring gene long non-coding RNA:CR44634 Neighboring gene long non-coding RNA:CR44635

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monitoring positional information during oogenesis in adult Drosophila. Fasano L, et al. Development, 1988 Oct. PMID 2855515
    2. The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Eldon E, et al. Development, 1994 Apr. PMID 7600965
    3. Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila. Kleve CD, et al. Dev Dyn, 2006 Jul. PMID 16607637
    4. Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4. Buttenschoen K, et al. Langenbecks Arch Surg, 2009 Mar. PMID 18546014
    5. Roles of Toll-like receptors in innate immune responses. Takeda K, et al. Genes Cells, 2001 Sep. PMID 11554921

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Median mRNA expression of TLR2 and TLR4 of mononuclear cells was not altered, and there was no obvious trend over time.
      Title: Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4.
    2. 18W protein plays an adhesive or signaling role in regions of the epithelium engaged in cell migration.
      Title: Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila.
    3. Data show that in larvae, 18wheeler is required for normal fat body development, and in mutant larvae induction of all antimicrobial peptide genes is compromised.
      Title: Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antibacterial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    18 wheeler
    Names
    18-wheeler
    18Wheeler
    18w-PA
    CG8896-PA
    Toll-2
    toll like receptor
    toll receptor
    wheeler

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20111511..20116932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057466.2 → NP_476814.1  18 wheeler [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBR2, Q2XXS4
      Related
      FBpp0085620, FBtr0086309
      Conserved Domains (6) summary
      smart00082
      Location:679 → 736
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:1045 → 1183
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:210 → 464
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:212 → 236
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:866 → 907
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:235 → 295
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBR2 A1ZBR2
    Q24591 Q24591
    Q2XXS4 Q2XXS4
    Q7JPR9 Q7JPR9
    Q961H0 Q961H0

    Gene LinkOut

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