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    Kal1 Kallmann syndrome 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kal1provided by FlyBase
    Official Full Name
    Kallmann syndrome 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039155
    Locus tag
    Dmel_CG6173
    See related
    AllianceGenome:FB:FBgn0039155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6173; CT19368; Dmel\CG6173; Dmkal; DmKal-1; kal-1; Kal-1
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to be involved in neuron differentiation. Located in external side of plasma membrane and extracellular region. Is expressed in several structures, including amnioserosa; border follicle cell; cephalopharyngeal skeleton; embryonic segment; and gut section. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kal1 in Genome Data Viewer
    Location:
    95E1-95E5; 3-83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24141395..24147490)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19967117..19973212)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 10 Neighboring gene Niemann-Pick type C-2f Neighboring gene Seryl-tRNA synthetase-like insect mitochondrial protein Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of the Drosophila Kallmann's syndrome protein DmKal-1. Andrenacci D, et al. BMC Genet, 2006 Oct 11. PMID 17034626, Free PMC Article
    2. Invertebrate models of kallmann syndrome: molecular pathogenesis and new disease genes. Di Schiavi E, et al. Curr Genomics, 2013 Mar. PMID 23997646, Free PMC Article
    3. Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1. Andrenacci D, et al. Gene Expr Patterns, 2004 Nov. PMID 15533820
    4. Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis. Millo H, et al. Mech Dev, 2004 Nov. PMID 15454264
    5. New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans. Graze RM, et al. Genetics, 2007 Aug. PMID 17565959, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kallmann syndrome 1
    Names
    CG6173-PA
    Kal1-PA
    kal-1
    kallmann
    kallmann syndrome 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24141395..24147490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142963.3 → NP_651220.3  kallmann syndrome 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651220.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTT2, Q8WS92, Q9VCC7
      Related
      FBpp0083934
      Conserved Domains (2) summary
      pfam00041
      Location:177 → 245
      fn3; Fibronectin type III domain
      pfam00095
      Location:96 → 139
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SS0 Q95SS0
    Q9VCC7 Q9VCC7

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