Mgtor Megator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mgtorprovided by FlyBase
Official Full Name: Megatorprovided by FlyBase
Primary source: FLYBASE:FBgn0013756
Locus tag: Dmel_CG8274
See related: AllianceGenome:FB:FBgn0013756
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bx34; CG8274; Dmel\CG8274; l(2)k03905; mtor; Mtor; MTOR; Tpr; TPR
Summary: Enables chromatin DNA binding activity and histone acetyltransferase binding activity. Involved in several processes, including regulation of mitotic nuclear division; regulation of transcription by RNA polymerase II; and spindle organization. Located in several cellular components, including euchromatin; nucleus; and spindle. Part of nuclear pore. Is expressed in adult brain cell body rind; adult head; adult optic lobe; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48C5-48C5; 2-65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11852617..11861202)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7740122..7748707)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Title: TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
mTOR-S6K1 pathway mediates cytoophidium assembly
Title: mTOR-S6K1 pathway mediates cytoophidium assembly.
Data indicate a role for ubiquilins as regulators of autophagy by controlling mTOR serine-threonine kinases (mTOR)signalling.
Title: Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
Data show that the spindle matrix complex, including Chromator/Chriz (Chro), Megator (Mtor), and enhanced adult sensory threshold (East), has a novel nuclear function in reactivation of neural stem cells (NSCs).
Title: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.
Mtor is required for the correct centrosome orientation, mitotic spindle formation, and chromosome segregation.
Title: The Nuclear Matrix Protein Megator Regulates Stem Cell Asymmetric Division through the Mitotic Checkpoint Complex in Drosophila Testes.
WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
Data show that the spindle matrix protein Megator requires its coiled-coil amino-terminal domain for spindle matrix localization.
Title: A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis.
Reduced TOR activity promotes grk translation independent of the canonical Vasa-RNA helicase and cap-dependent mechanism.
Title: Modulation of gurken translation by insulin and TOR signaling in Drosophila.
Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb.
Title: Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in male germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metaphase plate congression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic sister chromatid separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	HMP more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in sex-chromosome dosage compensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
NOT located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in metaphase plate	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	HDA more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle matrix	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: megator

Names: CG8274-PA; CG8274-PB; Mgtor-PA; Mgtor-PB; lethal (2) k03905

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11852617..11861202

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273974.1 → NP_001260903.1 megator, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260903.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z8P9, O01385

UniProtKB/TrEMBL

A0A0B4KFE9

Conserved Domains (5) summary

cd00187
Location:1398 → 1605

TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...

TIGR04523
Location:177 → 911

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam07926
Location:1031 → 1158

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09728
Location:1201 → 1476

Taxilin; Myosin-like coiled-coil protein

pfam13863
Location:833 → 915

DUF4200; Domain of unknown function (DUF4200)
NM_057719.4 → NP_477067.2 megator, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477067.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z8P9, O01385

UniProtKB/TrEMBL

A0A0B4KFE9

Related

FBpp0087140

Conserved Domains (5) summary

cd00187
Location:1398 → 1605

TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...

TIGR04523
Location:177 → 911

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam07926
Location:1031 → 1158

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09728
Location:1201 → 1476

Taxilin; Myosin-like coiled-coil protein

pfam13863
Location:833 → 915

DUF4200; Domain of unknown function (DUF4200)