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    ATPsynCF6L ATP synthase, coupling factor 6-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38592, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ATPsynCF6Lprovided by FlyBase
    Official Full Name
    ATP synthase, coupling factor 6-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035585
    Locus tag
    Dmel_CG12027
    See related
    AllianceGenome:FB:FBgn0035585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATPR; CG12027; Dmel\CG12027
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP metabolic process. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and spermatozoon. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ATPsynCF6L in Genome Data Viewer
    Location:
    64C4-64C4; 3-13 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5011444..5012133, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5011444..5012133, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Connectin Neighboring gene long non-coding RNA:CR45685 Neighboring gene testis-specific gamma-tubulin ring protein 128 Neighboring gene long non-coding RNA:CR43884 Neighboring gene long non-coding RNA:CR46198

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila. Sawyer EM, et al. BMC Cell Biol, 2017 Mar 23. PMID 28335714, Free PMC Article
    2. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article
    3. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
    4. Two functionally different mitochondrial phosphate carriers support Drosophila melanogaster OXPHOS throughout distinct developmental stages. Curcio R, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37898376
    5. Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. Tripoli G, et al. Genome Biol, 2005. PMID 15693940, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase, coupling factor 6-like
    Names
    ATP synthase coupling factor 6
    ATPsynCF6L-PA
    CG12027-PA
    testis-enriched subunit F6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5011444..5012133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139685.2 → NP_647942.1  ATP synthase, coupling factor 6-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQ07, Q9VZ72
      Related
      FBpp0073228
      Conserved Domains (1) summary
      pfam05511
      Location:9 → 87
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZ72 Q9VZ72

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