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    Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon [ Mus musculus (house mouse) ]

    Gene ID: 26932, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp2r5eprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B', epsilonprovided by MGI
    Primary source
    MGI:MGI:1349473
    See related
    Ensembl:ENSMUSG00000021051 AllianceGenome:MGI:1349473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B56beta; 4633401M22Rik
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.3), CNS E11.5 (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r5e in Genome Data Viewer
    Location:
    12 C3; 12 32.75 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (75496237..75643064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (75449463..75596237, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member J Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene STARR-seq mESC enhancer starr_32491 Neighboring gene predicted gene, 34613 Neighboring gene glycoprotein hormone beta 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76550614-76550799 Neighboring gene STARR-seq mESC enhancer starr_32492 Neighboring gene STARR-seq mESC enhancer starr_32494 Neighboring gene STARR-seq mESC enhancer starr_32495 Neighboring gene STARR-positive B cell enhancer ABC_E2388 Neighboring gene predicted gene, 34666 Neighboring gene ribosomal protein lateral stalk subunit P2, pseudogene 1 Neighboring gene WD repeat domain 89

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. Brandt N, et al. FASEB J, 2008 Jul. PMID 18385213
    2. p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Okamoto K, et al. Mol Cell Biol, 1996 Nov. PMID 8887688, Free PMC Article
    3. Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. Martens E, et al. J Mol Biol, 2004 Feb 27. PMID 15095873
    4. Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. Dyson JJ, et al. FASEB Bioadv, 2022 Apr. PMID 35415460, Free PMC Article
    5. Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development. Götz J, et al. Mech Dev, 2000 May. PMID 10781942

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 4633401M22Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    Names
    protein phosphatase 2A subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012024.3 → NP_036154.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

      See identical proteins and their annotated locations for NP_036154.1

      Status: VALIDATED

      Source sequence(s)
      AC124414, AK132432
      Consensus CDS
      CCDS25983.1
      UniProtKB/Swiss-Prot
      Q3V1I5, Q571M6, Q61151, Q8C2M2
      Related
      ENSMUSP00000021447.8, ENSMUST00000021447.9
      Conserved Domains (2) summary
      pfam01603
      Location:55 → 435
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:2 → 67
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      75496237..75643064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515926.4 → XP_006515989.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2

      See identical proteins and their annotated locations for XP_006515989.1

      Conserved Domains (2) summary
      pfam01603
      Location:55 → 430
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:2 → 67
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. XM_006515925.4 → XP_006515988.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

      See identical proteins and their annotated locations for XP_006515988.1

      UniProtKB/Swiss-Prot
      Q3V1I5, Q571M6, Q61151, Q8C2M2
      Conserved Domains (2) summary
      pfam01603
      Location:55 → 435
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
      cl27532
      Location:2 → 67
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_006515927.5 → XP_006515990.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3

      Conserved Domains (1) summary
      pfam01603
      Location:30 → 410
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61151.3 GenPept UniProtKB/Swiss-Prot:Q61151

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