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    CG9521 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9521provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030588
    Locus tag
    Dmel_CG9521
    See related
    AllianceGenome:FB:FBgn0030588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dm GMCtheta2; Dmel\CG9521
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in ecdysteroid metabolic process. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9521 in Genome Data Viewer
    Location:
    12F6-12F6; 1-49 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14851005..14853269, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14745038..14747302, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46391 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila. Cavigliasso F, et al. PLoS Genet, 2024 Mar. PMID 38452112, Free PMC Article
    2. Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi H, et al. Biochem J, 2005 Aug 1. PMID 15813704, Free PMC Article
    3. Expansion and evolution of insect GMC oxidoreductases. Iida K, et al. BMC Evol Biol, 2007 May 11. PMID 17498303, Free PMC Article
    4. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
    5. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysteroid metabolic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in ecdysteroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9521-PA
    NP_572977.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14851005..14853269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132749.2 → NP_572977.1  uncharacterized protein Dmel_CG9521 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY10
      Related
      FBpp0073802
      Conserved Domains (3) summary
      PRK02106
      Location:57 → 614
      PRK02106; choline dehydrogenase; Validated
      pfam05199
      Location:465 → 609
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:125 → 356
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY10 Q9VY10

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