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    Idh3g Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idh3gprovided by FlyBase
    Official Full Name
    Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039358
    Locus tag
    Dmel_CG5028
    See related
    AllianceGenome:FB:FBgn0039358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5028; Dmel\CG5028
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Idh3g in Genome Data Viewer
    Location:
    96E9-96E9; 3-88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25680845..25683780)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21506567..21509502)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase Neighboring gene Lipophorin receptor 2 Neighboring gene long non-coding RNA:CR46102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. Zhou J, et al. PLoS Genet, 2019 Sep. PMID 31553718, Free PMC Article
    2. The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila. González Morales N, et al. J Cell Sci, 2023 Jul 1. PMID 37272588, Free PMC Article
    3. Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. Jeong J, et al. PLoS Genet, 2021 Oct. PMID 34714823, Free PMC Article
    4. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
    5. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. Lim DH, et al. J Cell Biochem, 2013 Feb. PMID 22961661

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isocitrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
    Names
    CG5028-PA
    CG5028-PB
    CG5028-PC
    CG5028-PD
    Idh3g-PA
    Idh3g-PB
    Idh3g-PC
    Idh3g-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25680845..25683780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104452.2 → NP_001097922.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT18, Q9VBN6
      Conserved Domains (1) summary
      TIGR00175
      Location:55 → 386
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. NM_001104453.2 → NP_001097923.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRB8
      Conserved Domains (1) summary
      TIGR00175
      Location:55 → 386
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. NM_143159.3 → NP_651416.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT18, Q9VBN6
      Related
      FBpp0084275
      Conserved Domains (1) summary
      TIGR00175
      Location:55 → 386
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    4. NM_001104454.2 → NP_001097924.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRC1
      Conserved Domains (1) summary
      TIGR00175
      Location:55 → 386
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JRB8 A8JRB8
    A8JRC1 A8JRC1
    Q8MT18 Q8MT18

    Gene LinkOut

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