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    nemy no extended memory [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nemyprovided by FlyBase
    Official Full Name
    no extended memoryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261673
    Locus tag
    Dmel_CG8776
    See related
    AllianceGenome:FB:FBgn0261673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.146; CG13147; CG8776; CytB561; Dmel\CG8776; Nemy; P153
    Old locus tag
    Dmel_CG8772
    Summary
    Predicted to enable transmembrane ascorbate ferrireductase activity. Involved in locomotory behavior; memory; and modulation of chemical synaptic transmission. Is expressed in several structures, including circulatory system primordium; embryonic/larval hemocyte; ganglia; midline glial cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nemy in Genome Data Viewer
    Location:
    49B11-49B12; 2-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12659497..12670219, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8547002..8557724, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Zinc transporter 49B Neighboring gene uncharacterized protein Neighboring gene Glutaminase Neighboring gene Nucleoporin 188kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel memory mutants in Drosophila: behavioral characteristics of the mutant nemyP153. Kamyshev NG, et al. BMC Neurosci, 2002 Jul 30. PMID 12149133, Free PMC Article
    2. Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy. Knight D, et al. PLoS One, 2015. PMID 26237434, Free PMC Article
    3. Identification of Drosophila mutant with memory defects after acquisition of conditioned reflex suppression of courtship. Kamyshev NG, et al. Neurosci Behav Physiol, 2000 May-Jun. PMID 10970024
    4. nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Iliadi KG, et al. Proc Natl Acad Sci U S A, 2008 Dec 16. PMID 19064935, Free PMC Article
    5. Comparison of insect and human cytochrome b561 proteins: Insights into candidate ferric reductases in insects. Holst JD, et al. PLoS One, 2023. PMID 38039324, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on metal ions ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    no extended memory
    Names
    CG8776-PA
    CG8776-PB
    CG8776-PC
    CG8776-PE
    CG8776-PG
    CG8776-PK
    CG8776-PL
    CG8776-PM
    DcytB-like
    cytochrome b561
    nemy-PA
    nemy-PB
    nemy-PC
    nemy-PE
    nemy-PG
    nemy-PK
    nemy-PL
    nemy-PM
    no-extended memory
    NP_001163128.1
    NP_001286358.1
    NP_001286359.1
    NP_610808.1
    NP_725208.1
    NP_725209.1
    NP_725210.1
    NP_725211.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12659497..12670219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165934.3 → NP_725208.1  no extended memory, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, Q7JR72
      Related
      FBpp0086980
      Conserved Domains (1) summary
      pfam03188
      Location:99 → 233
      Cytochrom_B561; Eukaryotic cytochrome b561

    2. NM_165935.3 → NP_725209.1  no extended memory, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, Q95T77
      Related
      FBpp0086983
      Conserved Domains (1) summary
      cl23723
      Location:56 → 254
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    3. NM_165936.3 → NP_725210.1  no extended memory, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, Q0E9A2
      Related
      FBpp0086982
      Conserved Domains (1) summary
      cl23723
      Location:3 → 197
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    4. NM_001169657.2 → NP_001163128.1  no extended memory, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, Q95T77
      Conserved Domains (1) summary
      cl23723
      Location:56 → 254
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    5. NM_001299429.1 → NP_001286358.1  no extended memory, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEY2, C0PTW4
      Conserved Domains (1) summary
      cl23723
      Location:56 → 253
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    6. NM_165937.3 → NP_725211.3  no extended memory, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725211.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, E2QCC2
      Conserved Domains (1) summary
      cl23723
      Location:3 → 196
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    7. NM_001299430.1 → NP_001286359.1  no extended memory, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF85, C0PTW4
      Conserved Domains (1) summary
      cl23723
      Location:46 → 243
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    8. NM_136964.4 → NP_610808.1  no extended memory, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTW4, Q95T77
      Related
      FBpp0086981
      Conserved Domains (1) summary
      cl23723
      Location:56 → 254
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEY2 A0A0B4LEY2
    A0A0B4LF85 A0A0B4LF85
    E2QCC2 E2QCC2
    Q0E9A2 Q0E9A2
    Q7JR72 Q7JR72
    Q95T77 Q95T77

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