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    MBD-like Methyl-CpG binding domain protein-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MBD-likeprovided by FlyBase
    Official Full Name
    Methyl-CpG binding domain protein-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027950
    Locus tag
    Dmel_CG8208
    See related
    AllianceGenome:FB:FBgn0027950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8208; Dm Mbd2/3; dMBD-like; dMbD2/3; dMBD2/3; Dmel\CG8208; DmMbd2/3; MBD2; MBD2-3; MBD2/3; MBD3
    Summary
    Enables several functions, including histone deacetylase binding activity; methyl-CpG binding activity; and protein homodimerization activity. Involved in chromosome condensation and negative regulation of DNA-templated transcription. Located in nucleus and polytene chromosome. Part of NuRD complex. Is expressed in several structures, including gonad and male germline cell. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including MBD3 (methyl-CpG binding domain protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MBD-like in Genome Data Viewer
    Location:
    85D24-85D24; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9559760..9561533)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5385482..5387255)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein S1 Neighboring gene uncharacterized protein Neighboring gene Branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene Adaptor Protein complex 1, mu subunit Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional repression by Drosophila methyl-CpG-binding proteins. Roder K, et al. Mol Cell Biol, 2000 Oct. PMID 10982856, Free PMC Article
    2. The effects of cadmium on the development of Drosophila and its transgenerational inheritance effects. Mu Y, et al. Toxicology, 2021 Oct. PMID 34508823
    3. DNA methylation learns to fly. Lyko F. Trends Genet, 2001 Apr. PMID 11275305
    4. Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Gupta T, et al. Sci Rep, 2017 Jul 14. PMID 28710457, Free PMC Article
    5. The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA. Marhold J, et al. Development, 2004 Dec. PMID 15537686

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that MBD-containing protein dMBD2/3 contribute to reproductive isolation and survival behavioral strategies.
      Title: Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila.
    2. results indicate that dMBD2/3 forms specialized nuclear compartments to keep certain genes epigenetically silenced during genome activation
      Title: Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables methyl-CpG binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Methyl-CpG binding domain protein-like
    Names
    CG8208-PA
    CG8208-PB
    CG8208-PC
    MBD-like-PA
    MBD-like-PB
    MBD-like-PC
    methyl-CpG-binding-domain-like-protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9559760..9561533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275492.1 → NP_001262421.1  Methyl-CpG binding domain protein-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ0
      Conserved Domains (3) summary
      pfam01429
      Location:13 → 98
      MBD; Methyl-CpG binding domain
      pfam14048
      Location:246 → 338
      MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
      pfam16564
      Location:172 → 241
      MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

    2. NM_169293.2 → NP_731370.1  Methyl-CpG binding domain protein-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHB7
      Related
      FBpp0081547
      Conserved Domains (3) summary
      pfam01429
      Location:13 → 97
      MBD; Methyl-CpG binding domain
      pfam14048
      Location:245 → 337
      MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
      pfam16564
      Location:171 → 240
      MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

    3. NM_141650.3 → NP_649907.1  Methyl-CpG binding domain protein-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V424
      Related
      FBpp0081546
      Conserved Domains (2) summary
      pfam14048
      Location:132 → 224
      MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
      pfam16564
      Location:58 → 127
      MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGZ0 A0A0B4KGZ0
    Q9V424 Q9V424
    Q9VHB7 Q9VHB7

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