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    ppk17 pickpocket 17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk17provided by FlyBase
    Official Full Name
    pickpocket 17provided by FlyBase
    Primary source
    FLYBASE:FBgn0032602
    Locus tag
    Dmel_CG13278
    See related
    AllianceGenome:FB:FBgn0032602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13278; Dmel\CG13278; Ppk17
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk17 in Genome Data Viewer
    Location:
    36A14-36A14; 2-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16758184..16760554, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16758184..16760554, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7 Neighboring gene Bub3 interacting GLEBS and Zinc finger domain protein Neighboring gene yellow-b Neighboring gene Myosin heavy chain Neighboring gene Cytochrome b5-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Ben-Shahar Y. Adv Genet, 2011. PMID 22099690, Free PMC Article
    2. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article
    3. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. Zelle KM, et al. G3 (Bethesda), 2013 Mar. PMID 23449991, Free PMC Article
    4. Identification of potential mechanosensitive ion channels involved in texture discrimination during Drosophila suzukii egg-laying behaviour. Guo L, et al. Insect Mol Biol, 2020 Oct. PMID 32596943
    5. Molecular and cellular basis of sodium sensing in Drosophila labellum. Asefa WR, et al. iScience, 2024 Jul 19. PMID 39015148, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 17
    Names
    CG13278-PA
    CG13278-PB
    ppk17-PA
    ppk17-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16758184..16760554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299059.1 → NP_001285988.1  pickpocket 17, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJI4
      Conserved Domains (1) summary
      cl02990
      Location:11 → 358
      ASC; Amiloride-sensitive sodium channel

    2. NM_135965.2 → NP_609809.1  pickpocket 17, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJI4
      Related
      FBpp0080487
      Conserved Domains (1) summary
      cl02990
      Location:11 → 358
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJI4 Q9VJI4

    Gene LinkOut

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