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    Tsp96F Tetraspanin 96F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp96Fprovided by FlyBase
    Official Full Name
    Tetraspanin 96Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027865
    Locus tag
    Dmel_CG6120
    See related
    AllianceGenome:FB:FBgn0027865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD19727; CG6120; Dm.Tsp96F; Dmel\CG6120; LD19727; tsp96F
    Summary
    Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6 and prostate adenocarcinoma. Orthologous to human CD81 (CD81 molecule); CD9 (CD9 molecule); and TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp96F in Genome Data Viewer
    Location:
    96F5-96F5; 3-89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25872900..25881427, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21698622..21707149, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Signal peptide peptidase-like Neighboring gene Lnk

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active Wnt proteins are secreted on exosomes. Gross JC, et al. Nat Cell Biol, 2012 Oct. PMID 22983114
    2. Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Linnemannstöns K, et al. J Extracell Vesicles, 2022 Sep. PMID 36103151, Free PMC Article
    3. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    4. Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium. Linnemannstöns K, et al. Development, 2020 Aug 14. PMID 32611603, Free PMC Article
    5. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 96F
    Names
    CG6120-PA
    CG6120-PB
    CG6120-PC
    Tetraspanin96F
    Tsp96F-PA
    Tsp96F-PB
    Tsp96F-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25872900..25881427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276048.2 → NP_001262977.1  tetraspanin 96F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3X2
      Conserved Domains (1) summary
      pfam00335
      Location:10 → 257
      Tetraspannin; Tetraspanin family

    2. NM_079776.3 → NP_524500.1  tetraspanin 96F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3X2
      Related
      FBpp0084286
      Conserved Domains (1) summary
      pfam00335
      Location:10 → 257
      Tetraspannin; Tetraspanin family

    3. NM_001276047.2 → NP_001262976.1  tetraspanin 96F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262976.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH03
      Conserved Domains (2) summary
      cd03155
      Location:107 → 233
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 261
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH03 A0A0B4KH03
    Q9V3X2 Q9V3X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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