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    AlaRS Alanyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34156, updated on 27-Dec-2024

    Summary

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    Official Symbol
    AlaRSprovided by FlyBase
    Official Full Name
    Alanyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027094
    Locus tag
    Dmel_CG13391
    See related
    AllianceGenome:FB:FBgn0027094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AARS; Aats-ala; alaS; ARS; CG13391; dAARS; Dmel\CG13391
    Summary
    Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and trichothiodystrophy. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AlaRS in Genome Data Viewer
    Location:
    29B3-29B3; 2-31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8378262..8381764, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8378262..8381764, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene WD repeat domain 82 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 4 Neighboring gene Defender against apoptotic cell death 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positional recognition of a tRNA determinant dependent on a peptide insertion. Lovato MA, et al. Mol Cell, 2004 Mar 26. PMID 15053877
    2. Translocation within the acceptor helix of a major tRNA identity determinant. Lovato MA, et al. EMBO J, 2001 Sep 3. PMID 11532948, Free PMC Article
    3. Drosophila growth and development in the absence of dMyc and dMnt. Pierce SB, et al. Dev Biol, 2008 Mar 15. PMID 18241851, Free PMC Article
    4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    5. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alanine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alanyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in alanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Alanyl-tRNA synthetase
    Names
    AlaRS-PA
    AlaRS-PB
    CG13391-PA
    CG13391-PB
    NP_523511.2
    NP_995656.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8378262..8381764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078787.4 → NP_523511.2  Alanyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523511.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9K4, Q9U6B4, Q9VLM8
      UniProtKB/TrEMBL
      T2FFB7
      Related
      FBpp0079326
      Conserved Domains (5) summary
      PLN02900
      Location:5 → 963
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:6 → 253
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      pfam02272
      Location:888 → 957
      DHHA1; DHHA1 domain
      pfam07973
      Location:694 → 752
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cl08469
      Location:529 → 626
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

    2. NM_205934.3 → NP_995656.1  Alanyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9K4, Q9U6B4, Q9VLM8
      UniProtKB/TrEMBL
      T2FFB7
      Conserved Domains (5) summary
      PLN02900
      Location:5 → 963
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:6 → 253
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      pfam02272
      Location:888 → 957
      DHHA1; DHHA1 domain
      pfam07973
      Location:694 → 752
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cl08469
      Location:529 → 626
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9G8 Q8T9G8
    Q9VLM8.1 Q9VLM8

    Gene LinkOut

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