U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    REPTOR-BP REPTOR-binding partner [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34371, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    REPTOR-BPprovided by FlyBase
    Official Full Name
    REPTOR-binding partnerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032202
    Locus tag
    Dmel_CG18619
    See related
    AllianceGenome:FB:FBgn0032202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH73910; CG18619; DM20; Dmel\CG18619; Reptor-BP
    Summary
    Enables chromatin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in TORC1 signaling; positive regulation of DNA-templated transcription; and response to starvation. Located in nucleus. Is expressed in several structures, including central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See REPTOR-BP in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10264125..10265229)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10264125..10265229)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatase and tensin homolog Neighboring gene Repressor splicing factor 1 Neighboring gene MOB kinase activator 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies. Xu J, et al. Elife, 2022 Jan 25. PMID 35076390, Free PMC Article
    2. The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Bjedov I, et al. Genes (Basel), 2020 Sep 3. PMID 32899412, Free PMC Article
    3. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
    4. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Tiebe M, et al. Dev Cell, 2015 May 4. PMID 25920570, Free PMC Article
    5. B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners. Fassler J, et al. Genome Res, 2002 Aug. PMID 12176927, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    REPTOR-binding partner
    Names
    CG18619-PA
    CG18619-PB
    CG18619-PC
    CG18619-PD
    REPTOR-BP-PA
    REPTOR-BP-PB
    REPTOR-BP-PC
    REPTOR-BP-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10264125..10265229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164904.2 → NP_723547.1  REPTOR-binding partner, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPC7
      Related
      FBpp0088676
      Conserved Domains (2) summary
      cd14686
      Location:43 → 88
      bZIP; coiled coil [structural motif]
      cl21462
      Location:42 → 88
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_164903.2 → NP_723546.1  REPTOR-binding partner, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723546.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYS1
      Related
      FBpp0088678
      Conserved Domains (1) summary
      cd14709
      Location:41 → 96
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

    3. NM_164905.3 → NP_723548.1  REPTOR-binding partner, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPC6
      Related
      FBpp0088677
      Conserved Domains (2) summary
      cd14686
      Location:42 → 87
      bZIP; coiled coil [structural motif]
      cl21462
      Location:41 → 87
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    4. NM_135519.3 → NP_609363.1  REPTOR-binding partner, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IPC6, Q8IPC7, Q8MYS1, Q9VL14
      Related
      FBpp0088679
      Conserved Domains (1) summary
      cd14709
      Location:42 → 97
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL14.2 Q9VL14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools