ClpP Caseinolytic protease proteolytic subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ClpPprovided by FlyBase
Official Full Name: Caseinolytic protease proteolytic subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0032229
Locus tag: Dmel_CG5045
See related: AllianceGenome:FB:FBgn0032229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5045; dClpP; Dmel\CG5045
Summary: Enables serine-type endopeptidase activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of endopeptidase Clp complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10356795..10358078)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10356795..10358078)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP-dependent peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables serine hydrolase activity	HDA more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial protein quality control	TAS Traceable Author Statement more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of endopeptidase Clp complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial endopeptidase Clp complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IC Inferred by Curator more info	PubMed

Names: CG5045-PA; CG5045-PB; Clp protease; Clp protease proteolytic subunit; ClpP-PA; ClpP-PB

NP_001260332.1

NP_609388.1

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The following sections contain reference sequences that belong to a specific genome build. Explain