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ClpP Caseinolytic protease proteolytic subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34402, updated on 9-Dec-2024

Summary

Official Symbol
ClpPprovided by FlyBase
Official Full Name
Caseinolytic protease proteolytic subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0032229
Locus tag
Dmel_CG5045
See related
AllianceGenome:FB:FBgn0032229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5045; dClpP; Dmel\CG5045
Summary
Enables serine-type endopeptidase activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of endopeptidase Clp complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See ClpP in Genome Data Viewer
Location:
31D10-31D10; 2-41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10356795..10358078)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10356795..10358078)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cathepsin L4 Neighboring gene Cullin-associated and neddylation-dissociated 1 Neighboring gene pimples

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent peptidase activity  
enables ATP-dependent peptidase activity  
enables ATPase binding  
enables serine hydrolase activity PubMed 
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity PubMed 
Component Evidence Code Pubs
part_of endopeptidase Clp complex  
part_of mitochondrial endopeptidase Clp complex PubMed 
is_active_in mitochondrial matrix PubMed 

General protein information

Preferred Names
caseinolytic protease proteolytic subunit
Names
CG5045-PA
CG5045-PB
Clp protease
Clp protease proteolytic subunit
ClpP-PA
ClpP-PB
NP_001260332.1
NP_609388.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10356795..10358078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273403.1 → NP_001260332.1  caseinolytic protease proteolytic subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AN47, Q9VKY3
    Conserved Domains (1) summary
    PRK00277
    Location:28 → 222
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed
  2. NM_135544.3 → NP_609388.1  caseinolytic protease proteolytic subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AN47, Q9VKY3
    Related
    FBpp0079590
    Conserved Domains (1) summary
    PRK00277
    Location:28 → 222
    clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed
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