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    Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Mus musculus (house mouse) ]

    Gene ID: 50781, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dkk3provided by MGI
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by MGI
    Primary source
    MGI:MGI:1354952
    See related
    Ensembl:ENSMUSG00000030772 AllianceGenome:MGI:1354952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dkk-3; mDkk-3
    Summary
    Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Located in extracellular space. Is expressed in several structures, including brain; cardiovascular system; limb; sensory organ; and tooth. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 37.0), bladder adult (RPKM 29.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dkk3 in Genome Data Viewer
    Location:
    7 F1; 7 58.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (111715226..111758689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112116019..112159482, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3960 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene STARR-positive B cell enhancer ABC_E10463 Neighboring gene STARR-seq mESC enhancer starr_19852 Neighboring gene STARR-positive B cell enhancer ABC_E6587 Neighboring gene predicted gene, 39071 Neighboring gene predicted gene, 39070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage. Xu Y, et al. J Neuroinflammation, 2020 Apr 24. PMID 32331523, Free PMC Article
    2. Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease. Zhang L, et al. J Alzheimers Dis, 2017. PMID 28922151
    3. Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice. Cheng WL, et al. J Am Heart Assoc, 2017 Feb 20. PMID 28219919, Free PMC Article
    4. Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse. Inoue J, et al. J Mol Histol, 2017 Feb. PMID 27866302
    5. Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity. Meister M, et al. J Invest Dermatol, 2015 Aug. PMID 25835957

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent manner.
      Title: DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner.
    2. Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
      Title: Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
    3. A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
      Title: A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
    4. Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
      Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
    5. Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
      Title: Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
    6. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
      Title: Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
    7. Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
      Title: Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
    8. Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
      Title: Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
    9. DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
      Title: DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
    10. Dkk3 maintains the integrity of secreting vesicles in mouse adrenal medulla by regulating the expression of chromogranin A and neuropeptide Y
      Title: Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of aldosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of aldosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cortisol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cortisol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dickkopf-related protein 3
    Names
    dickkopf homolog 3
    dickkopf-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360257.1 → NP_001347186.1  dickkopf-related protein 3 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC122343, FO707532

    2. NM_001360260.1 → NP_001347189.1  dickkopf-related protein 3 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC122343, AC166834
      Consensus CDS
      CCDS21752.1
      UniProtKB/Swiss-Prot
      Q9QUN9
      Conserved Domains (1) summary
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    3. NM_001360261.1 → NP_001347190.1  dickkopf-related protein 3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC122343, AC166834
      Conserved Domains (1) summary
      pfam04706
      Location:119 → 168
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    4. NM_015814.3 → NP_056629.1  dickkopf-related protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_056629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC166834, AK004853
      Consensus CDS
      CCDS21752.1
      UniProtKB/Swiss-Prot
      Q9QUN9
      Related
      ENSMUSP00000033036.6, ENSMUST00000033036.7
      Conserved Domains (1) summary
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      111715226..111758689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUN9.1 GenPept UniProtKB/Swiss-Prot:Q9QUN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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