Tagln transgelin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taglnprovided by MGI
Official Full Name: transgelinprovided by MGI
Primary source: MGI:MGI:106012
See related: Ensembl:ENSMUSG00000032085 AllianceGenome:MGI:106012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sm22; Sm22a; Ws310
Summary: This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
Expression: Biased expression in bladder adult (RPKM 3112.1), stomach adult (RPKM 1002.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 25.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45840926..45847356, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45929628..45936058, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
Title: Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization.
Title: Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
SM22alpha Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
Title: SM22α Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes.
SM22alpha cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
Title: SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
Deletion of SM22alpha disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
Title: Deletion of SM22α disrupts the structure and function of caveolae and T-tubules in cardiomyocytes, contributing to heart failure.
Smooth muscle protein 22alpha-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
Title: Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors.
Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
Title: Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
Title: The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
SM22alpha(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
Title: SM22α(+) vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling.
Smooth muscle 22alpha deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.
Title: Smooth muscle 22α deficiency impairs oxytocin-induced uterine contractility in mice at full-term pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548410

AA959856 (e-PCR)
- UniSTS:159869

Tagln (e-PCR), detects polymorphism
- UniSTS:525192

PMC193673P1 (e-PCR)
- UniSTS:271753

PMC153489P1 (e-PCR)
- UniSTS:271254

NoName (e-PCR)
- UniSTS:548528

MARC_7597-7598:992008547:1 (e-PCR)
- UniSTS:231351

MARC_7597-7598:996687993:1 (e-PCR)
- UniSTS:231351

PMC150745P2 (e-PCR)
- UniSTS:271102

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transgelin

Names: SM22-alpha; Sm22alpha; actin-associated protein p27; smooth muscle protein 22-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011526.5 → NP_035656.1 transgelin

Status: REVIEWED

Source sequence(s)

AC122273, AK077235

Consensus CDS

CCDS23137.1

UniProtKB/Swiss-Prot

P37804, Q545W0

Related

ENSMUSP00000034590.3, ENSMUST00000034590.4

Conserved Domains (3) summary

COG5199
Location:14 → 189

SCP1; Calponin [Cytoskeleton]

cd00014
Location:25 → 137

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00402
Location:175 → 198

Calponin; Calponin family repeat