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    DAS1 SCF ubiquitin ligase complex subunit DAS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAS1
    Official Full Name
    SCF ubiquitin ligase complex subunit DAS1
    Primary source
    SGD:S000003685
    Locus tag
    YJL149W
    See related
    AllianceGenome:SGD:S000003685; FungiDB:YJL149W; VEuPathDB:YJL149W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUH1
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAS1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (137379..139370)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene inositol-3-phosphate synthase INO1 Neighboring gene Sna3p Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA. Di Santo R, et al. Elife, 2016 Oct 1. PMID 27692069, Free PMC Article
    2. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Tang X, et al. Cell, 2007 Jun 15. PMID 17574027
    3. TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress. Gómez-Herreros F, et al. Nucleic Acids Res, 2012 Aug. PMID 22544605, Free PMC Article
    4. Galactose induction of the GAL1 gene requires conditional degradation of the Mig2 repressor. Lim MK, et al. Biochem J, 2011 May 1. PMID 21323640
    5. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci, 1999 Sep 29. PMID 10582239, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
      Title: Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SCF ubiquitin ligase complex subunit DAS1
    NP_012386.1
    • Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      137379..139370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181582.1 → NP_012386.1  TPA: SCF ubiquitin ligase complex subunit DAS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012386.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW36, P47005
      UniProtKB/TrEMBL
      A6ZQI1, B3LPX0, C8ZB71, N1P1G6
      Conserved Domains (1) summary
      pfam12937
      Location:49 → 92
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47005.1

    Gene LinkOut

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