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    CAC2 Cac2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAC2
    Official Full Name
    Cac2p
    Primary source
    SGD:S000004570
    Locus tag
    YML102W
    See related
    AllianceGenome:SGD:S000004570; FungiDB:YML102W; VEuPathDB:YML102W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in chromosome, centromeric region; cytosol; and nucleus. Part of CAF-1 complex. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAC2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (68294..69700)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Nup188p Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Cue4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cac2p
    NP_013605.1
    • Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      68294..69700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182464.1 → NP_013605.1  TPA: Cac2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0I2, Q04199
      UniProtKB/TrEMBL
      A6ZLW2, B3LLF6, N1P0G0
      Conserved Domains (2) summary
      sd00039
      Location:17 → 69
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:4 → 214
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04199.1

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