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    Rich RIC1 homolog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Richprovided by FlyBase
    Official Full Name
    RIC1 homologprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028500
    Locus tag
    Dmel_CG9063
    See related
    AllianceGenome:FB:FBgn0028500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3L6; BcDNA:GH03694; BcDNAGH03694; CG9063; Dmel\CG9063; rich
    Summary
    Enables small GTPase binding activity. Involved in several processes, including neuron development; protein localization to synapse; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including embryonic/larval optic lobe; eye disc; lamina anlage; medulla anlage; and synaptic neuropil domain. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rich in Genome Data Viewer
    Location:
    79D2-79D3; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22257749..22262921, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22250849..22256021, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene olf413 Neighboring gene long non-coding RNA:CR45972 Neighboring gene long non-coding RNA:CR45035 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA 3 Neighboring gene Dead-box-1 Neighboring gene Cysteine string protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila. Haag-Liautard C, et al. Nature, 2007 Jan 4. PMID 17203060
    2. Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors. Iwanami N, et al. PLoS Genet, 2016 Feb. PMID 26890939, Free PMC Article
    3. Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Tong C, et al. Neuron, 2011 Aug 11. PMID 21835342, Free PMC Article
    4. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. Riedel F, et al. J Cell Biol, 2018 Feb 5. PMID 29273580, Free PMC Article
    5. The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila. Deshpande M, et al. Traffic, 2016 Feb. PMID 26538429

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RIC1 homolog
    Names
    CG9063-PA
    CG9063-PB
    Rich-PA
    Rich-PB
    ric1 homolog
    ric1 homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22257749..22262921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275276.1 → NP_001262205.1  RIC1 homolog, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PG00, Q9V3C5
      Conserved Domains (2) summary
      pfam07064
      Location:713 → 974
      RIC1; RIC1
      sd00039
      Location:265 → 312
      7WD40; WD40 repeat [structural motif]

    2. NM_141128.3 → NP_649385.1  RIC1 homolog, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PG00, Q9V3C5
      Related
      FBpp0078164
      Conserved Domains (2) summary
      pfam07064
      Location:713 → 974
      RIC1; RIC1
      sd00039
      Location:265 → 312
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3C5.1 Q9V3C5

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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