emc extra macrochaetae [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: emcprovided by FlyBase
Official Full Name: extra macrochaetaeprovided by FlyBase
Primary source: FLYBASE:FBgn0000575
Locus tag: Dmel_CG1007
See related: AllianceGenome:FB:FBgn0000575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0094/26; 0203/10; 0587/01; 0977/09; Ach; bHLHb28; CG1007; Dm0688; Dmel\CG1007; Emc; gov; l(3)04322; l(3)05592; l(3)61Da; l(3)j4E11; ms(3)61CD
Summary: Enables transcription corepressor activity. Involved in several processes, including compound eye morphogenesis; digestive tract development; and embryonic development via the syncytial blastoderm. Located in nucleus. Is expressed in several structures, including epithelium; follicle cell; ganglia; germ layer; and gut section. Orthologous to several human genes including ID3 (inhibitor of DNA binding 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61C9-61C9; 3-0.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (749400..753492)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (749400..753492)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.
Title: The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.
EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel.
Title: EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel.
provides initial insights into the mechanisms underlying the function of daughterless and Emc in neurons while providing a novel understanding of how Emc functions to restrict daughterless activity within the cell
Title: Extramacrochaetae promotes branch and bouton number via the sequestration of daughterless in the cytoplasm of neurons.
post-transcriptional mechanisms contribute more to regulation of Emc protein levels than transcriptional mechanisms do.
Title: Transcriptional and post-transcriptional regulation of extra macrochaetae during Drosophila adult peripheral neurogenesis.
Daughterless level sets Emc protein levels in most cells, apparently by stabilizing Emc in heterodimers. Emc is destabilized in proneural regions by local competition for heterodimer formation by proneural bHLH proteins including Atonal or AS-C proteins.
Title: Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners.
emc is required for the left-right asymmetric morphogenesis of embryonic hindgut. Emc suppression of Daughterless is essential for development.
Title: E and ID proteins regulate cell chirality and left-right asymmetric development in Drosophila.
Notch signaling activates the expression of extramacrochaetae (emc), which encodes a helix-loop-helix (HLH) transcription factor. Emc, in turn, then forms a biochemical complex with Da.
Title: Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.
Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs.
Title: Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs.
Hh drives and Emc impedes the progression of the furrow across the developing retina.
Title: Hedgehog and extramacrochaetae in the Drosophila eye: an irresistible force meets an immovable object.
we show that during the development of epithelial cells in the imaginal discs, the G2/M transition, and hence cell proliferation, is controlled by Emc via Da. In eukaryotic cells, the main activator of this transition is the Cdc25 phosphatase, string
Title: The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0688 (e-PCR)
- UniSTS:78666

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R3/R4 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in chorion-containing eggshell pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in photoreceptor cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extra macrochaetae

Names: CG1007-PA; achetous; emc-PA; extra macroachaetae; extra macrochaete; extra macrocheatae; extramachrochaetae; extramacrochaetae; extramacrochaete; extramacrocheatae; extramacrocheate; golovan; male sterile(3)61CD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

749400..753492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079152.4 → NP_523876.2 extra macrochaetae [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523876.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P18491, Q9W0N0

Related

FBpp0072477

Conserved Domains (1) summary

cd00083
Location:37 → 80

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...