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    Sap47 Synapse-associated protein 47kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sap47provided by FlyBase
    Official Full Name
    Synapse-associated protein 47kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013334
    Locus tag
    Dmel_CG8884
    See related
    AllianceGenome:FB:FBgn0013334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8884; Dmel\CG8884; dsap-47; SAP 47; SAP-47; sap47; SAP47
    Summary
    Involved in associative learning and regulation of short-term neuronal synaptic plasticity. Located in synapse. Is expressed in adult brain; adult head; embryonic/larval head sense organ; embryonic/larval neuromuscular junction; and ganglia. Orthologous to human SYAP1 (synapse associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sap47 in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15935100..15962124)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11760822..11787846)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 7 Neighboring gene uncharacterized protein Neighboring gene black pearl Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47. Saumweber T, et al. J Neurosci, 2011 Mar 2. PMID 21368063, Free PMC Article
    2. The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals. Reichmuth C, et al. Brain Res Mol Brain Res, 1995 Aug. PMID 7494462
    3. Synapsin is required to "boost" memory strength for highly salient events. Kleber J, et al. Learn Mem, 2016 Jan. PMID 26670182, Free PMC Article
    4. Targeted mutagenesis of the Sap47 gene of Drosophila: flies lacking the synapse associated protein of 47 kDa are viable and fertile. Funk N, et al. BMC Neurosci, 2004 Apr 29. PMID 15117418, Free PMC Article
    5. BSD: a novel domain in transcription factors and synapse-associated proteins. Doerks T, et al. Trends Biochem Sci, 2002 Apr. PMID 11943536

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
      Title: Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
    2. SAP47 is required for proper behavior and synaptic plasticity.
      Title: Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47.
    3. The conserved synaptic protein SAP47 of Drosophila is not essential for basic synaptic function. The Sap47 gene region may be refractory to targeted mutagenesis by homologous recombination
      Title: Targeted mutagenesis of the Sap47 gene of Drosophila: flies lacking the synapse associated protein of 47 kDa are viable and fertile.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of short-term neuronal synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Synapse-associated protein 47kD
    Names
    CG8884-PA
    CG8884-PB
    CG8884-PC
    CG8884-PD
    CG8884-PE
    CG8884-PF
    CG8884-PG
    CG8884-PI
    CG8884-PJ
    CG8884-PK
    CG8884-PL
    CG8884-PM
    Sap47-PA
    Sap47-PB
    Sap47-PC
    Sap47-PD
    Sap47-PE
    Sap47-PF
    Sap47-PG
    Sap47-PI
    Sap47-PJ
    Sap47-PK
    Sap47-PL
    Sap47-PM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15935100..15962124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370053.1 → NP_001356917.1  Synapse-associated protein 47kD, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K1Y5
      Conserved Domains (1) summary
      smart00751
      Location:274 → 324
      BSD; domain in transcription factors and synapse-associated proteins

    2. NM_001300421.1 → NP_001287350.1  Synapse-associated protein 47kD, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH71
      Conserved Domains (1) summary
      smart00751
      Location:274 → 324
      BSD; domain in transcription factors and synapse-associated proteins

    3. NM_169688.3 → NP_732092.2  Synapse-associated protein 47kD, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732092.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH71
      Conserved Domains (1) summary
      smart00751
      Location:274 → 324
      BSD; domain in transcription factors and synapse-associated proteins

    4. NM_169684.3 → NP_732088.1  Synapse-associated protein 47kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
      Related
      FBpp0082658
      Conserved Domains (1) summary
      smart00751
      Location:297 → 347
      BSD; domain in transcription factors and synapse-associated proteins

    5. NM_169690.3 → NP_732094.1  Synapse-associated protein 47kD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960T2
      Related
      FBpp0082659
      Conserved Domains (1) summary
      smart00751
      Location:297 → 347
      BSD; domain in transcription factors and synapse-associated proteins

    6. NM_079647.4 → NP_524371.1  Synapse-associated protein 47kD, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524371.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960T2
      Related
      FBpp0082663
      Conserved Domains (1) summary
      smart00751
      Location:274 → 324
      BSD; domain in transcription factors and synapse-associated proteins

    7. NM_169686.3 → NP_732090.1  Synapse-associated protein 47kD, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
      Related
      FBpp0082661
      Conserved Domains (1) summary
      smart00751
      Location:297 → 347
      BSD; domain in transcription factors and synapse-associated proteins

    8. NM_169687.3 → NP_732091.1  Synapse-associated protein 47kD, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732091.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
      Related
      FBpp0082662
      Conserved Domains (1) summary
      smart00751
      Location:297 → 347
      BSD; domain in transcription factors and synapse-associated proteins

    9. NM_001370054.1 → NP_001356918.1  Synapse-associated protein 47kD, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K595
      Conserved Domains (1) summary
      smart00751
      Location:281 → 331
      BSD; domain in transcription factors and synapse-associated proteins

    10. NM_169689.3 → NP_732093.1  Synapse-associated protein 47kD, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960T2
      Related
      FBpp0082664
      Conserved Domains (1) summary
      smart00751
      Location:281 → 331
      BSD; domain in transcription factors and synapse-associated proteins

    11. NM_169685.3 → NP_732089.1  Synapse-associated protein 47kD, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
      Related
      FBpp0082660
      Conserved Domains (1) summary
      smart00751
      Location:297 → 347
      BSD; domain in transcription factors and synapse-associated proteins

    12. NM_001275688.1 → NP_001262617.1  Synapse-associated protein 47kD, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDF6
      Conserved Domains (1) summary
      smart00751
      Location:271 → 321
      BSD; domain in transcription factors and synapse-associated proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH71 A0A0B4LH71
    A0A4D6K1Y5 A0A4D6K1Y5
    A0A4D6K595 A0A4D6K595
    F3YDF6 F3YDF6
    Q960T2.1 Q960T2

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