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    Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 16452, updated on 14-Jan-2025

    Summary

    Official Symbol
    Jak2provided by MGI
    Official Full Name
    Janus kinase 2provided by MGI
    Primary source
    MGI:MGI:96629
    See related
    Ensembl:ENSMUSG00000024789 AllianceGenome:MGI:96629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fd17
    Summary
    Enables interleukin-12 receptor binding activity; protein tyrosine kinase activity; and signaling receptor activator activity. Involved in several processes, including cell surface receptor signaling pathway; hemopoiesis; and positive regulation of metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to dexamethasone stimulus; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.6), CNS E18 (RPKM 6.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Jak2 in Genome Data Viewer
    Location:
    19 C1; 19 23.73 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29229006..29290495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29251803..29313095)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45880 Neighboring gene microRNA 101b Neighboring gene predicted gene 5518 Neighboring gene STARR-seq mESC enhancer starr_45881 Neighboring gene STARR-positive B cell enhancer ABC_E11673 Neighboring gene predicted gene, 41829 Neighboring gene STARR-seq mESC enhancer starr_45882 Neighboring gene STARR-seq mESC enhancer starr_45883 Neighboring gene insulin-like 6 Neighboring gene relaxin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables ATP binding  
    enables SH2 domain binding  
    enables SH2 domain binding  
    enables acetylcholine receptor binding  
    enables acetylcholine receptor binding  
    enables growth hormone receptor binding  
    enables growth hormone receptor binding  
    enables growth hormone receptor binding  
    enables heme binding  
    enables heme binding  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables histone H3Y41 kinase activity  
    enables histone binding  
    enables histone binding  
    enables identical protein binding  
    enables identical protein binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables interleukin-12 receptor binding PubMed 
    enables metal ion binding  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables peptide hormone receptor binding  
    enables peptide hormone receptor binding  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    enables signaling receptor activator activity PubMed 
    enables signaling receptor binding  
    enables type 1 angiotensin receptor binding  
    enables type 1 angiotensin receptor binding  
    Items 1 - 25 of 39
    Items 1 - 25 of 159
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in activation of Janus kinase activity PubMed 
    involved_in adaptive immune response  
    involved_in axon regeneration  
    involved_in axon regeneration  
    acts_upstream_of_or_within cell differentiation PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within cellular response to dexamethasone stimulus PubMed 
    acts_upstream_of_or_within cellular response to interleukin-3 PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated signaling pathway  
    involved_in collagen-activated signaling pathway  
    involved_in cytokine-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway PubMed 
    involved_in cytokine-mediated signaling pathway PubMed 
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
    involved_in defense response to symbiont PubMed 
    acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway PubMed 
    involved_in erythrocyte differentiation  
    involved_in erythrocyte differentiation PubMed 
    involved_in erythropoietin-mediated signaling pathway  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway PubMed 
    involved_in granulocyte-macrophage colony-stimulating factor signaling pathway  
    involved_in granulocyte-macrophage colony-stimulating factor signaling pathway  
    involved_in growth hormone receptor signaling pathway  
    involved_in growth hormone receptor signaling pathway  
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in growth hormone receptor signaling pathway via JAK-STAT PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT  
    involved_in hormone-mediated signaling pathway  
    involved_in hormone-mediated signaling pathway  
    involved_in immune response PubMed 
    involved_in interleukin-12-mediated signaling pathway  
    involved_in interleukin-12-mediated signaling pathway  
    involved_in interleukin-23-mediated signaling pathway  
    involved_in interleukin-3-mediated signaling pathway  
    involved_in interleukin-3-mediated signaling pathway  
    involved_in interleukin-5-mediated signaling pathway  
    involved_in interleukin-5-mediated signaling pathway  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within intracellular signal transduction PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress  
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress  
    involved_in lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within mammary gland epithelium development PubMed 
    involved_in microglial cell activation PubMed 
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of chemical synaptic transmission  
    acts_upstream_of_or_within myeloid cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of DNA binding PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell-cell adhesion  
    involved_in negative regulation of cell-cell adhesion  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of neuron apoptotic process  
    involved_in nuclear receptor-mediated mineralocorticoid signaling pathway  
    involved_in nuclear receptor-mediated mineralocorticoid signaling pathway  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MHC class II biosynthetic process PubMed 
    involved_in positive regulation of NK T cell proliferation  
    involved_in positive regulation of NK T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of T cell proliferation PubMed 
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of T-helper 17 type immune response PubMed 
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
    involved_in positive regulation of cell activation  
    involved_in positive regulation of cell activation  
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of epithelial cell apoptotic process  
    involved_in positive regulation of epithelial cell apoptotic process  
    involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  
    involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  
    involved_in positive regulation of growth hormone receptor signaling pathway PubMed 
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of interleukin-1 beta production PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-17 production PubMed 
    involved_in positive regulation of leukocyte proliferation  
    involved_in positive regulation of natural killer cell proliferation  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of platelet activation  
    acts_upstream_of_or_within positive regulation of platelet activation  
    involved_in positive regulation of platelet aggregation  
    acts_upstream_of positive regulation of platelet aggregation  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of type II interferon production  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in post-embryonic hemopoiesis PubMed 
    involved_in post-translational protein modification  
    involved_in post-translational protein modification  
    involved_in protein autophosphorylation PubMed 
    involved_in regulation of apoptotic process  
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    involved_in regulation of nitric oxide biosynthetic process  
    involved_in regulation of postsynapse to nucleus signaling pathway  
    involved_in regulation of postsynapse to nucleus signaling pathway  
    involved_in response to amine  
    acts_upstream_of_or_within response to antibiotic PubMed 
    involved_in response to granulocyte macrophage colony-stimulating factor PubMed 
    involved_in response to hydroperoxide  
    involved_in response to hydroperoxide  
    involved_in response to interleukin-12  
    involved_in response to interleukin-12  
    involved_in response to oxidative stress  
    involved_in response to oxidative stress  
    involved_in response to tumor necrosis factor  
    involved_in response to tumor necrosis factor  
    involved_in signal transduction PubMed 
    acts_upstream_of_or_within symbiont-induced defense-related programmed cell death PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in type II interferon-mediated signaling pathway  
    involved_in type II interferon-mediated signaling pathway  
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
    Items 1 - 25 of 159
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    located_in caveola PubMed 
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoskeleton  
    is_active_in cytosol  
    located_in cytosol  
    located_in endomembrane system  
    located_in euchromatin  
    located_in euchromatin  
    located_in extrinsic component of cytoplasmic side of plasma membrane  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane  
    is_active_in extrinsic component of plasma membrane  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    part_of granulocyte macrophage colony-stimulating factor receptor complex  
    part_of granulocyte macrophage colony-stimulating factor receptor complex  
    part_of interleukin-12 receptor complex PubMed 
    part_of interleukin-23 receptor complex PubMed 
    located_in membrane raft PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynapse  
    is_active_in postsynapse  
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    tyrosine-protein kinase JAK2
    Names
    JAK-2
    NP_001041642.1
    NP_032439.2
    XP_006526776.1
    XP_006526777.1
    XP_006526778.1
    XP_011245457.1
    XP_017173557.1
    XP_036017342.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048177.3NP_001041642.1  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_001041642.1

      Status: VALIDATED

      Source sequence(s)
      AC119228, AC162456
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Related
      ENSMUSP00000025705.7, ENSMUST00000025705.7
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
    2. NM_008413.4NP_032439.2  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_032439.2

      Status: VALIDATED

      Source sequence(s)
      AC119228, AC162456
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Related
      ENSMUSP00000064394.4, ENSMUST00000065796.10
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29229006..29290495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161449.1XP_036017342.1  tyrosine-protein kinase JAK2 isoform X5

      UniProtKB/TrEMBL
      A0A494BBB9
      Related
      ENSMUSP00000158405.2, ENSMUST00000236990.2
      Conserved Domains (5) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:545592
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006526715.5XP_006526778.1  tyrosine-protein kinase JAK2 isoform X5

      UniProtKB/TrEMBL
      A0A494BBB9
      Conserved Domains (5) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:545592
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006526713.5XP_006526776.1  tyrosine-protein kinase JAK2 isoform X2

      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd14205
      Location:7991082
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:548761
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011247155.3XP_011245457.1  tyrosine-protein kinase JAK2 isoform X1

      See identical proteins and their annotated locations for XP_011245457.1

      UniProtKB/Swiss-Prot
      G5E852, Q62120, Q62124, Q7TQD0
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39134
      FERM_F1; FERM F1 ubiquitin-like domain
    5. XM_017318068.3XP_017173557.1  tyrosine-protein kinase JAK2 isoform X4

      Conserved Domains (3) summary
      cd05078
      Location:140401
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:439722
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cl15255
      Location:177
      SH2; Src homology 2 (SH2) domain
    6. XM_006526714.5XP_006526777.1  tyrosine-protein kinase JAK2 isoform X3

      Conserved Domains (5) summary
      cd10379
      Location:190286
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:70190
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:349610
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:648931
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:1065
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
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