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    Fam210b family with sequence similarity 210, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam210bprovided by RGD
    Official Full Name
    family with sequence similarity 210, member Bprovided by RGD
    Primary source
    RGD:1311378
    See related
    EnsemblRapid:ENSRNOG00000004466 AllianceGenome:RGD:1311378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311378
    Summary
    Predicted to be involved in cellular response to estradiol stimulus and positive regulation of erythrocyte differentiation. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human FAM210B (family with sequence similarity 210 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 409.0), Liver (RPKM 240.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam210b in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (181536665..181546830)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161118228..161128400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170354109..170364265)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dynein heavy chain-like Neighboring gene uncharacterized LOC102550081 Neighboring gene aurora kinase A Neighboring gene cleavage stimulation factor subunit 1 Neighboring gene Cas scaffold protein family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. Kondo A, et al. Int J Hematol, 2016 Apr. PMID 26968549
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM210B, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106547.4 → NP_001100017.1  protein FAM210B, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001100017.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KKW6, B2RYM8, F7FD17
      Conserved Domains (1) summary
      pfam06916
      Location:85 → 172
      DUF1279; Protein of unknown function (DUF1279)

    2. NM_001430303.1 → NP_001417232.1  protein FAM210B, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430304.1 → NP_001417233.1  protein FAM210B, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KKW6, B2RYM8, F7FD17

    4. NM_001430305.1 → NP_001417234.1  protein FAM210B, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      181536665..181546830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104648.2 → XP_038960576.1  protein FAM210B, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam06916
      Location:85 → 119
      DUF1279; Protein of unknown function (DUF1279)

    2. XM_006235677.5 → XP_006235739.1  protein FAM210B, mitochondrial isoform X1

      Related
      ENSRNOP00000005901.2, ENSRNOT00000005901.6
      Conserved Domains (1) summary
      pfam06916
      Location:85 → 172
      DUF1279; Protein of unknown function (DUF1279)

    3. XM_039104649.2 → XP_038960577.1  protein FAM210B, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam06916
      Location:26 → 113
      DUF1279; Protein of unknown function (DUF1279)

    4. XM_063283416.1 → XP_063139486.1  protein FAM210B, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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