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    Tmod3 tropomodulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 50875, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmod3provided by MGI
    Official Full Name
    tropomodulin 3provided by MGI
    Primary source
    MGI:MGI:1355315
    See related
    Ensembl:ENSMUSG00000058587 AllianceGenome:MGI:1355315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UTMOD; U-Tmod
    Summary
    Enables tropomyosin binding activity. Acts upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in striated muscle thin filament. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmod3 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75405066..75466939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75497784..75559657, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538 Neighboring gene predicted gene 7972 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene tropomodulin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding  
    enables microtubule minus-end binding  
    enables tropomyosin binding  
    enables tropomyosin binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoskeleton  
    part_of filamentous actin  
    located_in lamellipodium  
    is_active_in myofibril  
    located_in ruffle  
    is_active_in striated muscle thin filament  
    located_in striated muscle thin filament PubMed 

    General protein information

    Preferred Names
    tropomodulin-3
    Names
    tropomodulin 3; ubiquitous tropomodulin
    ubiquitous tropomodulin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357828.1NP_001344757.1  tropomodulin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC115880, AC123832
      UniProtKB/TrEMBL
      Q8C3Z3
      Conserved Domains (1) summary
      cl26161
      Location:60172
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_016963.2NP_058659.1  tropomodulin-3 isoform 1

      See identical proteins and their annotated locations for NP_058659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF237630, AK147017, BY067594
      Consensus CDS
      CCDS23344.1
      UniProtKB/Swiss-Prot
      Q3TIT1, Q9JHJ0
      UniProtKB/TrEMBL
      Q3TFA9
      Related
      ENSMUSP00000072087.8, ENSMUST00000072232.9
      Conserved Domains (2) summary
      cd00116
      Location:199311
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:5144
      Tropomodulin; Tropomodulin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75405066..75466939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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