EIF3I eukaryotic translation initiation factor 3 subunit I [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Iprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Iprovided by HGNC
Primary source: HGNC:HGNC:3272
See related: Ensembl:ENSG00000084623 MIM:603911; AllianceGenome:HGNC:3272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 51.3), ovary (RPKM 48.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (32222407..32236170)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (32080311..32094075)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (32688008..32701771)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
Title: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
Title: eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.
Title: circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer.
Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues.
Title: Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues.
eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis.
Title: eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis.
varying concentrations of TRIP-1 can participate in the nucleation of calcium phosphate polymorphs.
Title: TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs.
EIF3i may affect vesicular stomatitis virus (VSV) growth by regulating the host antiviral response in HeLa cells.
Title: EIF3i affects vesicular stomatitis virus growth by interacting with matrix protein.
High eIF3i expression is associated with melanoma.
Title: eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation.
Clusterin is an independent predictive factor for prognosis of hepatocellular carcinoma and it facilitates metastasis through EIF3I/Akt/MMP13 signaling.
Title: Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.
eIF3i is a proto-oncogene that drives colon oncogenesis by translationally upregulating COX-2 and activating the beta-catenin signaling pathway
Title: EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit I (EIF3I) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Rev	rev	HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit I (EIF3I), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74136 (e-PCR)
- UniSTS:43296

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

RH98843 (e-PCR)
- UniSTS:86360

SHGC-74533 (e-PCR)
- UniSTS:28294

RH71226 (e-PCR)
- UniSTS:24484

D1S1290 (e-PCR)
- UniSTS:149487

RH64484 (e-PCR)
- UniSTS:40176

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit I

Names: TGF-beta receptor-interacting protein 1; TGFbeta receptor-interacting protein 1; eukaryotic translation initiation factor 3 subunit 2; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; predicted protein of HQ2242

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394168.1 → NP_001381097.1 eukaryotic translation initiation factor 3 subunit I isoform 2

Status: VALIDATED

Source sequence(s)

AL049795, AL121991

Consensus CDS

CCDS90907.1

UniProtKB/TrEMBL

A0A7I2YQI2, A0A7I2YQI6

Related

ENSP00000503706.1, ENST00000678063.1

Conserved Domains (2) summary

sd00039
Location:14 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:6 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_003757.4 → NP_003748.1 eukaryotic translation initiation factor 3 subunit I isoform 1

See identical proteins and their annotated locations for NP_003748.1

Status: VALIDATED

Source sequence(s)

AL049795, AL121991

Consensus CDS

CCDS357.1

UniProtKB/Swiss-Prot

Q13347

UniProtKB/TrEMBL

A0A7P0MRT9, Q53HU7, Q5U0F4

Related

ENSP00000504061.1, ENST00000677711.2

Conserved Domains (2) summary

sd00039
Location:14 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:6 → 311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

32222407..32236170

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024450518.2 → XP_024306286.1 eukaryotic translation initiation factor 3 subunit I isoform X1

Related

ENST00000676957.1

Conserved Domains (2) summary

sd00039
Location:58 → 94

7WD40; WD40 repeat [structural motif]

cl25539
Location:34 → 178

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...