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    SAH1 adenosylhomocysteinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856766, updated on 9-Dec-2024

    Summary

    Official Symbol
    SAH1
    Official Full Name
    adenosylhomocysteinase
    Primary source
    SGD:S000000845
    Locus tag
    YER043C
    See related
    AllianceGenome:SGD:S000000845; FungiDB:YER043C; VEuPathDB:YER043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process; phosphatidylcholine biosynthetic process; and triglyceride metabolic process. Located in cytoplasm. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; hyperhomocysteinemia; and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See SAH1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (235770..237119, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene Erg28p Neighboring gene Mei4p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables adenosylhomocysteinase activity  
    enables adenosylhomocysteinase activity  
    enables adenosylhomocysteinase activity PubMed 
    enables hydrolase activity  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytosol  

    General protein information

    Preferred Names
    adenosylhomocysteinase
    NP_010961.3
    • S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      235770..237119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178934.3 → NP_010961.3  TPA: adenosylhomocysteinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010961.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU3, P39954
      UniProtKB/TrEMBL
      A6ZQZ2, B3LS56, B5VHH7, C7GSJ0, C8Z746, G2WCS6, N1P540
      Conserved Domains (1) summary
      smart00996
      Location:9 → 448
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
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