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    xmas xmas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xmasprovided by FlyBase
    Official Full Name
    xmasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286809
    Locus tag
    Dmel_CG46386
    See related
    AllianceGenome:FB:FBgn0286809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32561; CG32562; CG46386; CG8919; Dmel\CG46386; l(1)15Ea; m(1)3; ms(1)3; ms3; Xmas; xmas-1; xmas-2; Xmas-2
    Old locus tag
    Dmel_CG32561; Dmel_CG32562
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in poly(A)+ mRNA export from nucleus and positive regulation of transcription by RNA polymerase II. Located in nuclear periphery. Part of nuclear pore and transcription export complex 2. Is expressed in ovary and testis. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See xmas in Genome Data Viewer
    Location:
    15E7-15F1; 1-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17151231..17159306, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17048143..17053339, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S5a Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene bazooka Neighboring gene long non-coding RNA:CR44026 Neighboring gene Tubulin tyrosine ligase-like 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments. Kurshakova MM, et al. Dokl Biochem Biophys, 2023 Apr. PMID 37340289
    2. Alternative Splicing of the Xmas mRNA Encoding the mRNA Export Protein in Drosophila melanogaster. Kopytova DV, et al. Dokl Biochem Biophys, 2018 Mar. PMID 29779104
    3. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex. Kurshakova MM, et al. Dokl Biochem Biophys, 2024 Oct. PMID 39196529
    4. Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster. Kurshakova MM, et al. Dokl Biochem Biophys, 2021 May. PMID 33689068
    5. PCID2 Subunit of the Drosophila TREX-2 Complex Has Two RNA-Binding Regions. Vdovina YA, et al. Curr Issues Mol Biol, 2023 Jul 4. PMID 37504273, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
      Title: Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex.
    2. The Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments.
      Title: The Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments.
    3. Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster.
      Title: Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster.
    4. The Xmas-2 Homologues, the Main Component of the TREX-2 mRNA Export Complex.
      Title: The Xmas-2 Homologues, the Main Component of the TREX-2 mRNA Export Complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    xmas
    Names
    CG46386-PA
    CG46386-PB
    CG46386-PC
    X-linked male sterile 2
    transcript g
    xmas-1
    xmas-2
    xmas-PA
    xmas-PB
    xmas-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17151231..17159306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370033.1 → NP_001356948.1  xmas, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A4D6K557, C9QP61, D0IQ87, H1UUM5, Q8IR02, Q8MQS3, Q9U3V8, Q9U3V9, Q9VX76
      Conserved Domains (3) summary
      cd12457
      Location:12 → 82
      RRM_XMAS2; RNA recognition motif in X-linked male sterile 2 (Xmas-2) and similar proteins
      pfam03399
      Location:200 → 503
      SAC3_GANP; SAC3/GANP family
      pfam17380
      Location:638 → 827
      DUF5401; Family of unknown function (DUF5401)

    2. NM_080034.3 → NP_524773.2  xmas, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524773.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3V8

    3. NM_167558.2 → NP_728054.1  xmas, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3V9
      Related
      FBpp0423199
      Conserved Domains (2) summary
      cd12457
      Location:12 → 82
      RRM_XMAS2; RNA recognition motif in X-linked male sterile 2 (Xmas-2) and similar proteins
      pfam03399
      Location:252 → 484
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3V9.4 Q9U3V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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