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    Pal2 Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pal2provided by FlyBase
    Official Full Name
    Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0262728
    Locus tag
    Dmel_CG5472
    See related
    AllianceGenome:FB:FBgn0262728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0149856.5; CG5472; Dmel\CG5472; dPAL2; Pal; PAL; PAL2
    Summary
    Enables peptidylamidoglycolate lyase activity. Located in extracellular region. Is expressed in several structures, including adult brain; adult head; adult peripheral nervous system; embryonic central brain neurons; and embryonic head epidermis. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pal2 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23688077..23690838)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19575600..19578361)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sulfotransferase 1 Neighboring gene Sulfotransferase 3 Neighboring gene lethal (2) essential for life Neighboring gene uncharacterized protein Neighboring gene angel Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila. Park D, et al. Dev Biol, 2004 May 1. PMID 15081360
    2. Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. Han M, et al. J Neurochem, 2004 Jul. PMID 15198673
    3. Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. Kolhekar AS, et al. J Neurosci, 1997 Feb 15. PMID 9006979, Free PMC Article
    4. Dopaminergic mushroom body neurons in Drosophila: Flexibility of neuron identity in a model organism? Dvořáček J, et al. Neurosci Biobehav Rev, 2022 Apr. PMID 35131397
    5. Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics. Croset V, et al. Elife, 2018 Apr 19. PMID 29671739, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidylamidoglycolate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2
    Names
    CG5472-PA
    CG5472-PD
    CG5472-PE
    Pal2-PA
    Pal2-PD
    Pal2-PE
    Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase
    NP_001286776.1
    NP_525118.2
    NP_995929.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23688077..23690838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299847.1 → NP_001286776.1  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZT8, Q7KVI0, Q9GPF3, Q9W1L5
      UniProtKB/TrEMBL
      A0A0B4LG96
      Conserved Domains (1) summary
      cd14958
      Location:102 → 404
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

    2. NM_080379.5 → NP_525118.2  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525118.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZT8, Q7KVI0, Q9GPF3, Q9W1L5
      UniProtKB/TrEMBL
      A0A0B4LG96
      Related
      FBpp0088497
      Conserved Domains (1) summary
      cd14958
      Location:102 → 404
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

    3. NM_206207.3 → NP_995929.2  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995929.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZT8, Q7KVI0, Q9GPF3, Q9W1L5
      UniProtKB/TrEMBL
      A0A0B4LG96
      Conserved Domains (1) summary
      cd14958
      Location:102 → 404
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG96 A0A0B4LG96
    Q9W1L5.2 Q9W1L5

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