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    UK114 UK114 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UK114provided by FlyBase
    Official Full Name
    UK114provided by FlyBase
    Primary source
    FLYBASE:FBgn0086691
    Locus tag
    Dmel_CG15261
    See related
    AllianceGenome:FB:FBgn0086691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM01181; BG:DS07851.3; CG15261; Dmel\CG15261; DUK 114; DUK114
    Summary
    Predicted to enable deaminase activity. Involved in protein folding. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus inner layer; embryonic/larval posterior spiracle; and gut section. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UK114 in Genome Data Viewer
    Location:
    35D1-35D1; 2-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15274181..15275091, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15274181..15275091, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Uxt prefoldin-like subunit Neighboring gene yuri gagarin Neighboring gene Cullin 3 Neighboring gene long non-coding RNA:CR43682 Neighboring gene long non-coding RNA:CR45349

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone. Farkas A, et al. Biochem J, 2004 Oct 1. PMID 15250825, Free PMC Article
    2. The intriguing Ca2+ requirement of calpain activation. Friedrich P. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451413
    3. The calpain-system of Drosophila melanogaster: coming of age. Friedrich P, et al. Bioessays, 2004 Oct. PMID 15382138
    4. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
    5. Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge. Alias Z, et al. Proteomics, 2007 Oct. PMID 17907271

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning and characterization of DUK114, the Drosophila orthologue of UK114.
      Title: DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UK114
    Names
    CG15261-PA
    CG15261-PB
    UK114-PA
    UK114-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15274181..15275091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273536.1 → NP_001260465.1  UK114, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3W0
      Conserved Domains (1) summary
      cl10015
      Location:6 → 127
      YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...

    2. NM_135903.3 → NP_609747.1  UK114, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3W0
      Related
      FBpp0080305
      Conserved Domains (1) summary
      cl10015
      Location:6 → 127
      YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3W0.1 Q9V3W0

    Gene LinkOut

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