Gpdh1 Glycerol-3-phosphate dehydrogenase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gpdh1provided by FlyBase
Official Full Name: Glycerol-3-phosphate dehydrogenase 1provided by FlyBase
Primary source: FLYBASE:FBgn0001128
Locus tag: Dmel_CG9042
See related: AllianceGenome:FB:FBgn0001128
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha-GPD; alpha-Gpdh; alpha-GPDH; alpha-GPDH-1; alphaGpd; alphaGpdh; alphaGPDH; alphaGpdh-1; CG9042; dGpdh; Dmel\CG9042; DmG3PDH; DROGPDHA; G3pdh; G3PDH; GAPDH; Gdh; Gpd; GPD; GPDA; gpdh; Gpdh; GPDH; gpdh-1; GPDH-1; GPDH1; sn-Gpdh
Summary: Enables glycerol-3-phosphate dehydrogenase (NAD+) activity. Involved in several processes, including flight behavior; glycerol-3-phosphate biosynthetic process; and nicotinamide nucleotide metabolic process. Located in M band; Z disc; and cytosol. Is expressed in adult head; adult heart; and flight muscle cell. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to several human genes including GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26A3-26A3; 2-18 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5943643..5948968)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5943643..5948968)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila melanogaster larvae lacking both LDH and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux.
Title: Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.
Molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
Title: The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
Gene trees for the GPDH and GPO paralogs indicate that the genes expressed in the flight muscles are evolving very slowly presumably under strong purifying selection whereas the paralogs expressed in the testes are evolving more rapidly.
Title: The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.
molecular polymorphism associated with GPDH activity could be maintained in natural populations by selection related to adaptation to alcohol
Title: Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADH oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ethanol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerophosphate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Glycerol-3-phosphate dehydrogenase 1

Names: 5' gene; Alpha-Glycerophosphate dehydrogenase; CG9042-PA; CG9042-PB; CG9042-PC; CG9042-PE; CG9042-PF; CG9042-PG; Gpdh1-PA; Gpdh1-PB; Gpdh1-PC; Gpdh1-PE; Gpdh1-PF; Gpdh1-PG; alpha glycerophosphate dehydrogenase; alpha glycerophosphate dehydrogenase 1; alpha-glycerol phosphate dehydrogenase; alpha-glycerol-3-phosphate dehydrogenase; dehydrogenase; glycerol 3 phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase; glycerophosphate dehydrogenase; sn-glycerol 3-phosphate dehydrogenase; sn-glycerol-3-phosphate; sn-glycerol-3-phosphate dehydrogenase

NP_001260111.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NP_001260112.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NP_001260113.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NP_476565.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NP_476566.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NP_476567.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.8

EC 1.1.1.94

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5943643..5948968

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273184.2 → NP_001260113.1 Glycerol-3-phosphate dehydrogenase 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260113.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

M9PC43

Conserved Domains (1) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
NM_001273183.2 → NP_001260112.1 Glycerol-3-phosphate dehydrogenase 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260112.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

B5RIM9

Conserved Domains (1) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
NM_001273182.1 → NP_001260111.1 Glycerol-3-phosphate dehydrogenase 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

M9PET0

Conserved Domains (3) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

pfam01210
Location:7 → 175

NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

pfam07479
Location:202 → 337

NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NM_057218.4 → NP_476566.1 Glycerol-3-phosphate dehydrogenase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

M9PC43

Related

FBpp0078778

Conserved Domains (1) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
NM_057217.4 → NP_476565.1 Glycerol-3-phosphate dehydrogenase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476565.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

B5RIM9

Related

FBpp0078777

Conserved Domains (1) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
NM_057219.4 → NP_476567.1 Glycerol-3-phosphate dehydrogenase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476567.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0

UniProtKB/TrEMBL

M9PET0

Related

FBpp0078779

Conserved Domains (3) summary

TIGR03376
Location:6 → 343

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

pfam01210
Location:7 → 175

NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

pfam07479
Location:202 → 337

NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus