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    thoc6 thoc6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc6provided by FlyBase
    Official Full Name
    thoc6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036263
    Locus tag
    Dmel_CG5632
    See related
    AllianceGenome:FB:FBgn0036263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5632; Dmel\CG5632; Thoc6; THOC6
    Summary
    Predicted to be involved in mRNA export from nucleus. Part of THO complex. Orthologous to human THOC6 (THO complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See thoc6 in Genome Data Viewer
    Location:
    69A1-69A1; 3-38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12190696..12193688, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12185132..12186788, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 2 Neighboring gene Myo-inositol oxygenase Neighboring gene Esterase 6 Neighboring gene Esterase P Neighboring gene long non-coding RNA:CR45746 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
    2. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
    3. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859
    4. Birth and death of genes and functions in the beta-esterase cluster of Drosophila. Robin C, et al. J Mol Evol, 2009 Jul. PMID 19536450, Free PMC Article
    5. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Kopytova DV, et al. Genes Dev, 2010 Jan 1. PMID 20048002, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus in response to heat stress IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    thoc6
    Names
    CG5632-PA
    CG5632-PB
    CG5632-PC
    thoc6-PA
    thoc6-PB
    thoc6-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12190696..12193688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316441.1 → NP_001303370.1  thoc6, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q705B9, Q9VTV1
      UniProtKB/TrEMBL
      M9PEZ4
      Conserved Domains (3) summary
      COG2319
      Location:45 → 325
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:159 → 194
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:115 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_140300.4 → NP_648557.1  thoc6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q705B9, Q9VTV1
      UniProtKB/TrEMBL
      M9PEZ4
      Related
      FBpp0075751
      Conserved Domains (3) summary
      COG2319
      Location:45 → 325
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:159 → 194
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:115 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001274821.1 → NP_001261750.1  thoc6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q705B9, Q9VTV1
      UniProtKB/TrEMBL
      M9PEZ4
      Conserved Domains (3) summary
      COG2319
      Location:45 → 325
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:159 → 194
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:115 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEZ4 M9PEZ4
    Q9VTV1.1 Q9VTV1

    Gene LinkOut

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