U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    kmo-1 Kynurenine 3-monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 179657, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    kmo-1
    Official Full Name
    Kynurenine 3-monooxygenase
    Primary source
    WormBase:WBGene00011089
    Locus tag
    CELE_R07B7.5
    See related
    AllianceGenome:WB:WBGene00011089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kynurenine 3-monooxygenase activity. Predicted to be involved in NAD metabolic process and kynurenine metabolic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See kmo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (12068724..12070519, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene FAD-binding domain-containing protein Neighboring gene Nucleotid_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. van der Goot AT, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927396, Free PMC Article
    2. Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans. Higurashi S, et al. Elife, 2023 May 30. PMID 37252859, Free PMC Article
    3. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article
    4. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine 3-monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Kynurenine 3-monooxygenase
    NP_506025.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12068724..12070519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073624.7 → NP_506025.1  Kynurenine 3-monooxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21795
      Conserved Domains (2) summary
      COG0644
      Location:4 → 436
      FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
      cl21454
      Location:4 → 363
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21795.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous