let-711 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-711
Official Full Name: CCR4-NOT transcription complex subunit let-711
Primary source: WormBase:WBGene00002845
Locus tag: CELE_F57B9.2
See related: AllianceGenome:WB:WBGene00002845
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable molecular adaptor activity. Involved in several processes, including microtubule cytoskeleton organization; nematode larval development; and post-transcriptional regulation of gene expression. Located in cytoplasm. Part of CCR4-NOT complex. Is expressed in germ line; gonad; and in male. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-711 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 18

Sequence:: Chromosome: III; NC_003281.10 (6946718..6958894)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

let-711 is required for spindle positioning in the early embryo
Title: LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-156 (e-PCR)
- UniSTS:241997

F57B9.2 (e-PCR)
- UniSTS:311902

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IDA Inferred from Direct Assay more info	PubMed
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCR4-NOT core complex	IEA Inferred from Electronic Annotation more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit let-711

NP_001333557.1

Confirmed by transcript evidence

NP_001333558.1

Confirmed by transcript evidence

NP_001333559.1

Confirmed by transcript evidence

NP_001368611.1

Confirmed by transcript evidence

NP_498516.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6946718..6958894

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066115.6 → NP_498516.3 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498516.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1D3PCL8, A0A1D3PCL9, A0A1D3PCM5, Q20937, S5ZDJ9

Conserved Domains (4) summary

PHA03378
Location:832 → 990

PHA03378; EBNA-3B; Provisional

COG5103
Location:1035 → 2602

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam04054
Location:2235 → 2599

Not1; CCR4-Not complex component, Not1

pfam16418
Location:592 → 743

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_001379782.1 → NP_001368611.1 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

PHA03378
Location:815 → 973

PHA03378; EBNA-3B; Provisional

COG5103
Location:1018 → 2585

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam04054
Location:2218 → 2582

Not1; CCR4-Not complex component, Not1

pfam16418
Location:575 → 726

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_001346615.3 → NP_001333557.1 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1D3PCL8

Conserved Domains (4) summary

PHA03378
Location:525 → 683

PHA03378; EBNA-3B; Provisional

COG5103
Location:728 → 2295

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam04054
Location:1935 → 2292

Not1; CCR4-Not complex component, Not1

pfam16418
Location:285 → 436

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
NM_001346616.3 → NP_001333558.1 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

S5ZDJ9

Conserved Domains (3) summary

PHA03378
Location:66 → 197

PHA03378; EBNA-3B; Provisional

COG5103
Location:269 → 1836

CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]

pfam04054
Location:1476 → 1833

Not1; CCR4-Not complex component, Not1
NM_001346617.3 → NP_001333559.1 CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1D3PCL9

Conserved Domains (1) summary

pfam04054
Location:1 → 215

Not1; CCR4-Not complex component, Not1