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    btbd-10 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btbd-10
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00019888
    Locus tag
    CELE_R05F9.1
    See related
    AllianceGenome:WB:WBGene00019888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including enteric muscle; hypodermal cell; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human BTBD10 (BTB domain containing 10) and KCTD20 (potassium channel tetramerization domain containing 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See btbd-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (4905008..4911835)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene SGTA homodimerization domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene snRNA-activating protein complex subunit 1 Neighboring gene P-type domain-containing protein Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Nawa M, et al. Cell Death Differ, 2012 Aug. PMID 22388351, Free PMC Article
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_001367754.1
    • Confirmed by transcript evidence
    NP_001379870.1
    • Confirmed by transcript evidence
    NP_740981.1
    • Confirmed by transcript evidence
    NP_740982.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4905008..4911835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170983.7 → NP_740981.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21747
      Conserved Domains (2) summary
      pfam05109
      Location:79 → 181
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18318
      Location:232 → 328
      BTB_POZ_KCTD20-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10)

    2. NM_001381405.1 → NP_001367754.1  BTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP41

    3. NM_001393055.1 → NP_001379870.1  BTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NF2
      Conserved Domains (1) summary
      cd18318
      Location:31 → 127
      BTB_POZ_KCTD20-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10)

    4. NM_170984.4 → NP_740982.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21748
      Conserved Domains (1) summary
      cd18318
      Location:135 → 231
      BTB_POZ_KCTD20-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10)
    Nucleotide Protein
    Heading Accession and Version

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