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    osm-6 Intraflagellar transport protein 52 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osm-6
    Official Full Name
    Intraflagellar transport protein 52 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00003886
    Locus tag
    CELE_R31.3
    See related
    AllianceGenome:WB:WBGene00003886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including cellular response to salt; non-motile cilium assembly; and sensory perception of mechanical stimulus. Located in several cellular components, including ciliary basal body; ciliary transition zone; and neuronal cell body. Is expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human IFT52 (intraflagellar transport 52). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See osm-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (11924621..11927446, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein;Ubiquitin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Alpha-mannosidase Neighboring gene Secreted protein Neighboring gene Enolase-phosphatase E1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imaging adult C. elegans live using light-sheet microscopy. VAN Krugten J, et al. J Microsc, 2021 Mar. PMID 32949409, Free PMC Article
    2. When females produce sperm: genetics of C. elegans hermaphrodite reproductive choice. Bahrami AK, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979940, Free PMC Article
    3. Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. Collet J, et al. Genetics, 1998 Jan. PMID 9475731, Free PMC Article
    4. UNC-115, a conserved protein with predicted LIM and actin-binding domains, mediates axon guidance in C. elegans. Lundquist EA, et al. Neuron, 1998 Aug. PMID 9728919
    5. Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip. Mijalkovic J, et al. Cell Rep, 2018 Nov 13. PMID 30428341

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Intraflagellar transport protein 52 C-terminal domain-containing protein
    NP_741633.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11924621..11927446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171545.9 → NP_741633.1  Intraflagellar transport protein 52 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDF6
      Conserved Domains (2) summary
      cl16912
      Location:202 → 228
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
      cl23805
      Location:50 → 122
      ABC_transp_aux; ABC-type uncharacterized transport system
    Nucleotide Protein
    Heading Accession and Version

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