U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    KIN28 TFIIH complex serine/threonine-protein kinase subunit KIN28 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851450, updated on 9-Dec-2024

    Summary

    Official Symbol
    KIN28
    Official Full Name
    TFIIH complex serine/threonine-protein kinase subunit KIN28
    Primary source
    SGD:S000002266
    Locus tag
    YDL108W
    See related
    AllianceGenome:SGD:S000002266; FungiDB:YDL108W; VEuPathDB:YDL108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in RNA metabolic process; positive regulation of autophagy; and positive regulation of transcription elongation by RNA polymerase II. Located in cytosol and nucleus. Part of transcription factor TFIIK complex. Used to study brachydactyly type A2; breast cancer; essential hypertension; glucose metabolism disease (multiple); and primary congenital glaucoma. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIN28 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (267698..268699)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tma17p Neighboring gene putative lipase Neighboring gene Mss2p Neighboring gene Pho2p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of serine/threonine protein kinase complex  
    part_of transcription factor TFIIH holo complex PubMed 
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIK complex  
    part_of transcription factor TFIIK complex PubMed 
    part_of transcription factor TFIIK complex  

    General protein information

    Preferred Names
    TFIIH complex serine/threonine-protein kinase subunit KIN28
    NP_010175.1
    • Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      267698..268699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180167.1 → NP_010175.1  TPA: TFIIH complex serine/threonine-protein kinase subunit KIN28 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP2, P06242
      UniProtKB/TrEMBL
      A6ZXM1, B3LGZ9, C8Z6J6, G2WC54, N1P423
      Conserved Domains (1) summary
      cd07841
      Location:7 → 302
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
    External link. Please review our privacy policy.