Snorc secondary ossification center associated regulator of chondrocyte maturation [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snorcprovided by MGI
Official Full Name: secondary ossification center associated regulator of chondrocyte maturationprovided by MGI
Primary source: MGI:MGI:1920484
See related: Ensembl:ENSMUSG00000026258 AllianceGenome:MGI:1920484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3110079O15Rik
Summary: Involved in cartilage development. Located in collagen-containing extracellular matrix. Is expressed in cartilage; knee; skeletal system; testis; and trachea. Orthologous to human SNORC (secondary ossification center associated regulator of chondrocyte maturation). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 44.2) and mammary gland adult (RPKM 24.9) See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 44.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87397734..87403204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87470201..87475482)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Snorc is expressed postnatally in knee epiphyses especially by prehypertrophic chondrocytes delineating the cartilage canals and secondary ossification center. Snorc core protein binds to FGF2 and inhibits FGF2 dependent cell growth of C3H101/2 cells. In Snorc deficient mice, Snorc deficiency caused defects in secondary ossification and growth plate maturation associated with increased Ihh and reduced MMP13 expression.
Title: Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency.
a novel cartilage-specific molecule, Snorc, was identified that may have functions associated with development and maintenance of chondrocyte phenotype
Title: Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein SNORC

Names: protein SNORC transcript; secondary ossification center-associated regulator of chondrocyte maturation protein; uncharacterized protein C2orf82 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356490.2 → NP_001343419.1 protein SNORC isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC157811

Conserved Domains (1) summary

pfam15756
Location:25 → 120

DUF4690; Domain of unknown function (DUF4690)
NM_028473.3 → NP_082749.1 protein SNORC isoform 1 precursor

See identical proteins and their annotated locations for NP_082749.1

Status: VALIDATED

Source sequence(s)

AC157811

Consensus CDS

CCDS48305.1

UniProtKB/Swiss-Prot

Q08EF5, Q9CXL7

UniProtKB/TrEMBL

A0A0A7EP66

Related

ENSMUSP00000027476.5, ENSMUST00000027476.6

Conserved Domains (1) summary

pfam15756
Location:26 → 121

DUF4690; Domain of unknown function (DUF4690)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

87397734..87403204

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153761.1 → XP_036009654.1 protein SNORC isoform X1

UniProtKB/Swiss-Prot

Q08EF5, Q9CXL7

UniProtKB/TrEMBL

A0A0A7EP66

Conserved Domains (1) summary

pfam15756
Location:26 → 121

DUF4690; Domain of unknown function (DUF4690)