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    Chic2 cysteine-rich hydrophobic domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83835, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chic2provided by RGD
    Official Full Name
    cysteine-rich hydrophobic domain 2provided by RGD
    Primary source
    RGD:1309278
    See related
    EnsemblRapid:ENSRNOG00000002267 AllianceGenome:RGD:1309278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in Golgi apparatus. Predicted to be active in Golgi-associated vesicle and plasma membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CHIC2 (cysteine rich hydrophobic domain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 142.4), Spleen (RPKM 107.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chic2 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (33511839..33546181)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (33157669..33192015)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (35683657..35718005)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene GS homeobox 2 Neighboring gene RB binding protein 4, chromatin remodeling factor, pseudogene 3 Neighboring gene uncharacterized LOC120096595 Neighboring gene uncharacterized LOC134481742

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi-associated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine-rich hydrophobic domain-containing protein 2
    Names
    cysteine-rich hydrophobic domain 2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105736.2NP_001099206.1  cysteine-rich hydrophobic domain-containing protein 2

      See identical proteins and their annotated locations for NP_001099206.1

      Status: VALIDATED

      Source sequence(s)
      BE109715, BE112096, BF558018, BF567482
      UniProtKB/TrEMBL
      A6JD10, B6RGM6, G3V6A1
      Related
      ENSRNOP00000003085.4, ENSRNOT00000003085.9
      Conserved Domains (1) summary
      pfam10256
      Location:46134
      Erf4; Golgin subfamily A member 7/ERF4 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      33511839..33546181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)