Sult1d1 sulfotransferase family 1D, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sult1d1provided by MGI
Official Full Name: sulfotransferase family 1D, member 1provided by MGI
Primary source: MGI:MGI:1926341
See related: Ensembl:ENSMUSG00000029273 AllianceGenome:MGI:1926341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ST1d1; Sultn; SULT-N; 5033411P13Rik
Summary: Enables aryl sulfotransferase activity. Acts upstream of or within sulfate assimilation and sulfation. Predicted to be active in cytoplasm. Is expressed in gut; olfactory epithelium; and urinary system. Orthologous to human SULT1D1P (sulfotransferase family 1D member 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 10.5), large intestine adult (RPKM 5.3) and 6 other tissues See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (87702509..87716865, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87554650..87569006, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sult1d1 knockout did not influence furfuryl alcohol bioactivation or the formation of hemoglobin adducts.
Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
Sult1d1 in mice is directly induced by glucocorticoids and may attenuate elevated catecholamine activity during the stress response.
Title: Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.
active sites of PAPS-dependent SULT1D1 and phenolic sulfate-utilizing ASST represent an example of convergent evolution.
Title: On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases.
the crystal structure of mouse sulfotransferase, mSULT1D1, complexed with donor substrate 3'-phosphoadenosine 5'-phosphosulfate and accepter substrate p-nitrophenol was reported.
Title: Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate.
Data obtained indicated that mSULT1D1 comprises of a single alpha/beta domain with a five-stranded parallel beta-sheet.
Title: Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase.
The mechanism underlying the broad range substrate specificity of mSULT1D1 is proposed based on the two newly determined crystal structures.
Title: Structural basis for the broad range substrate specificity of a novel mouse cytosolic sulfotransferase--mSULT1D1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE105744 (e-PCR)
- UniSTS:245900

AF026073 (e-PCR)
- UniSTS:159385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sulfate assimilation	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sulfotransferase 1 family member D1

Names: N-sulfotransferase; amine N-sulfotransferase; dopamine sulfotransferase Sult1d1; tyrosine-ester sulfotransferase

NP_058051.3

EC 2.8.2.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.